Nucleophosmin 1 (NPM1) protein is a multifunctional nucleolar chaperone and its gene is the most frequently mutated in Acute Myeloid Leukemia (AML). AML mutations cause the unfolding of the C-terminal domain (CTD) and the protein delocalizing in the cytosol (NPM1c+). Marked aggregation endowed with an amyloid character was assessed as consequences of mutations.
Type C mutation of nucleophosmin 1 acute myeloid leukemia: Consequences of intrinsic disorder / La Manna, S.; Florio, D.; Di Natale, C.; Lagreca, E.; Sibillano, T.; Giannini, C.; Marasco, D.. - In: BIOCHIMICA ET BIOPHYSICA ACTA. GENERAL SUBJECTS. - ISSN 1872-8006. - 1866:8(2022), p. 130173. [10.1016/j.bbagen.2022.130173]
Type C mutation of nucleophosmin 1 acute myeloid leukemia: Consequences of intrinsic disorder
La Manna S.;Florio D.;Di Natale C.;Lagreca E.;Marasco D.
2022
Abstract
Nucleophosmin 1 (NPM1) protein is a multifunctional nucleolar chaperone and its gene is the most frequently mutated in Acute Myeloid Leukemia (AML). AML mutations cause the unfolding of the C-terminal domain (CTD) and the protein delocalizing in the cytosol (NPM1c+). Marked aggregation endowed with an amyloid character was assessed as consequences of mutations.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
