Over the years, fullerenes have been covalently linked to other polar structures, increasing its aqueous solubility, thereby improving its potential use for biological and biomedical applications.1 The functionalization of C60, the most study fullerene, with biomolecules shows one of the best approaches to increase their bioavailability and access the benefits of these molecules.2 C60 derivatives have shown antioxidants and antivirals propierties. In adition, remarkable examples relate with the synthesis of C60 hybrids, where the [60]fullerene is covalently connected to biological active compounds such as sugars and steroids have affinity to some nucleic acids, proteins and cellular receptors.3 In the frame of a consolidated research focused on the versatility of steroid-C60 hybrids,4 we propose the synthesis of new methanofullerenes 1 (Scheme 1) containing selenium with potential antiviral and antioxidant propierties by a synergistic activity of selenium and the C60. The new methano[60]fullerenes were prepared using a cyclopropanation reaction employed the Bingel–Hirsch protocol in a multistep synthetic procedure. The precursors malonates contained three sterols – diosgenine, cholesterol, and stradiol – and a D-selenodeoxysugar 3. These conjugates were synthetized in good yields based on the consolidated synthetic technique performed previously by our reserch group5 and a computational study was carried out. Theoretical calculations using the DFT-PBE method and 6-311G(d,p) basis set, were performed to predict the most stable conformations for the synthesized conjugates (2). For the more, the applications of the novel steroid-selenosugar conjugates were also evaluated in medicinal chemistry, in particular, was explored their potential application as anti-SarsCov-2 agents. The molecular docking suggested that the conjugates form H-bonds with the active residues involved in the interaction of RBD-SarsCov-2 with ACE-2. How RBD protein plays an important role in the entry of virus in the cellule, the conjugates could be considerate with potential antivirals propierties.

Fullerene-derivates containing selenium

Silvana Pedatella
2022

Abstract

Over the years, fullerenes have been covalently linked to other polar structures, increasing its aqueous solubility, thereby improving its potential use for biological and biomedical applications.1 The functionalization of C60, the most study fullerene, with biomolecules shows one of the best approaches to increase their bioavailability and access the benefits of these molecules.2 C60 derivatives have shown antioxidants and antivirals propierties. In adition, remarkable examples relate with the synthesis of C60 hybrids, where the [60]fullerene is covalently connected to biological active compounds such as sugars and steroids have affinity to some nucleic acids, proteins and cellular receptors.3 In the frame of a consolidated research focused on the versatility of steroid-C60 hybrids,4 we propose the synthesis of new methanofullerenes 1 (Scheme 1) containing selenium with potential antiviral and antioxidant propierties by a synergistic activity of selenium and the C60. The new methano[60]fullerenes were prepared using a cyclopropanation reaction employed the Bingel–Hirsch protocol in a multistep synthetic procedure. The precursors malonates contained three sterols – diosgenine, cholesterol, and stradiol – and a D-selenodeoxysugar 3. These conjugates were synthetized in good yields based on the consolidated synthetic technique performed previously by our reserch group5 and a computational study was carried out. Theoretical calculations using the DFT-PBE method and 6-311G(d,p) basis set, were performed to predict the most stable conformations for the synthesized conjugates (2). For the more, the applications of the novel steroid-selenosugar conjugates were also evaluated in medicinal chemistry, in particular, was explored their potential application as anti-SarsCov-2 agents. The molecular docking suggested that the conjugates form H-bonds with the active residues involved in the interaction of RBD-SarsCov-2 with ACE-2. How RBD protein plays an important role in the entry of virus in the cellule, the conjugates could be considerate with potential antivirals propierties.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/901681
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