ADP-ribosylation (ADPr) is a biologically and clinically important post-translational modification, but little is known about the amino acids it targets on cellular proteins. Here we present a proteomic approach for direct in vivo identification and quantification of ADPr sites on histones. We have identified 12 unique ADPr sites in human osteosarcoma cells and report serine ADPr as a new type of histone mark that responds to DNA damage.

Serine is a new target residue for endogenous ADP-ribosylation on histones / Leidecker, O; Bonfiglio, Jj; Colby, T; Zhang, Q; Atanassov, I; Zaja, R; Palazzo, L; Stockum, A; Ahel, I; Matic, I.. - In: NATURE CHEMICAL BIOLOGY. - ISSN 1552-4450. - (2016). [10.1038/nchembio.2180]

Serine is a new target residue for endogenous ADP-ribosylation on histones

Palazzo L;
2016

Abstract

ADP-ribosylation (ADPr) is a biologically and clinically important post-translational modification, but little is known about the amino acids it targets on cellular proteins. Here we present a proteomic approach for direct in vivo identification and quantification of ADPr sites on histones. We have identified 12 unique ADPr sites in human osteosarcoma cells and report serine ADPr as a new type of histone mark that responds to DNA damage.
2016
Serine is a new target residue for endogenous ADP-ribosylation on histones / Leidecker, O; Bonfiglio, Jj; Colby, T; Zhang, Q; Atanassov, I; Zaja, R; Palazzo, L; Stockum, A; Ahel, I; Matic, I.. - In: NATURE CHEMICAL BIOLOGY. - ISSN 1552-4450. - (2016). [10.1038/nchembio.2180]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/901026
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 181
  • ???jsp.display-item.citation.isi??? 164
social impact