Objectives: To explore perinatal outcomes in SARS-CoV-2 vaccinated pregnant women comparing with unvaccinated counterparts. Methods: Search was conducted using Web of Science, Scopus, ClinicalTrial.gov, MEDLINE, Embase, OVID and Cochrane Library as electronic databases. We included observational studies evaluating pregnant women undergoing SARS-CoV-2 vaccination and compared pregnancy and perinatal outcomes with unvaccinated ones. Categorical variables were assessed using Odds Ratio (OR) with 95% Confidence Interval (CI), while for continuous variables results were expressed as Mean difference (MD) with their 95% Confidence Interval. All analyses were performed by adopting the random effect model of DerSimonian and Laird. Results: There is no difference in the probability of having a small for gestational age fetus (OR 0.97, 95% CI 0.85-1.09; p=0.570), while we observed a reduced probability of a non-reassuring fetal monitoring, a reduced gestational age at delivery and a reduced probability of premature delivery in vaccinated pregnant women versus unvaccinated ones. Conclusion: The probability of small for gestational age is similar between vaccinated and unvaccinated pregnant women, and the former had also a slightly reduced rate of premature delivery. Keywords: COVID-19; SARS-CoV-2; meta-analysis; pregnancy; preterm birth; small for gestational age; systematic review; vaccine.

COVID-19 vaccine and pregnancy outcomes: a systematic review and meta-analysis / Carbone, L; Trinchillo, Mg; Di Girolamo, R; Raffone, A; Saccone, G; Iorio, Gg; Gabrielli, O; Maruotti, Gm. - In: INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS. - ISSN 0020-7292. - (2022). [10.1002/ijgo.14336]

COVID-19 vaccine and pregnancy outcomes: a systematic review and meta-analysis

Raffone A;Saccone G;Iorio GG;Gabrielli O;Maruotti GM
2022

Abstract

Objectives: To explore perinatal outcomes in SARS-CoV-2 vaccinated pregnant women comparing with unvaccinated counterparts. Methods: Search was conducted using Web of Science, Scopus, ClinicalTrial.gov, MEDLINE, Embase, OVID and Cochrane Library as electronic databases. We included observational studies evaluating pregnant women undergoing SARS-CoV-2 vaccination and compared pregnancy and perinatal outcomes with unvaccinated ones. Categorical variables were assessed using Odds Ratio (OR) with 95% Confidence Interval (CI), while for continuous variables results were expressed as Mean difference (MD) with their 95% Confidence Interval. All analyses were performed by adopting the random effect model of DerSimonian and Laird. Results: There is no difference in the probability of having a small for gestational age fetus (OR 0.97, 95% CI 0.85-1.09; p=0.570), while we observed a reduced probability of a non-reassuring fetal monitoring, a reduced gestational age at delivery and a reduced probability of premature delivery in vaccinated pregnant women versus unvaccinated ones. Conclusion: The probability of small for gestational age is similar between vaccinated and unvaccinated pregnant women, and the former had also a slightly reduced rate of premature delivery. Keywords: COVID-19; SARS-CoV-2; meta-analysis; pregnancy; preterm birth; small for gestational age; systematic review; vaccine.
2022
COVID-19 vaccine and pregnancy outcomes: a systematic review and meta-analysis / Carbone, L; Trinchillo, Mg; Di Girolamo, R; Raffone, A; Saccone, G; Iorio, Gg; Gabrielli, O; Maruotti, Gm. - In: INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS. - ISSN 0020-7292. - (2022). [10.1002/ijgo.14336]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/900657
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