The single-stranded RNA genome of SARS-CoV-2 contains some G-quadruplex-forming G-rich elements which are putative drug targets. Here, we performed a ligand-based pharmacophore virtual screening of FDA approved drugs to find candidates targeting such RNA structures. Further in silico and in vitro assays identified three drugs as emerging SARS-CoV-2 RNA G-quadruplex binders.

Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders

Moraca F.;Marzano S.;Lupia A.;Di Porzio A.;Catalanotti B.;Randazzo A.;Pagano B.
;
Amato J.
2022

Abstract

The single-stranded RNA genome of SARS-CoV-2 contains some G-quadruplex-forming G-rich elements which are putative drug targets. Here, we performed a ligand-based pharmacophore virtual screening of FDA approved drugs to find candidates targeting such RNA structures. Further in silico and in vitro assays identified three drugs as emerging SARS-CoV-2 RNA G-quadruplex binders.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/899768
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