Phytochemical investigation of Penicillium sp. RO-11 strain, collected from the sediments of a hydrothermal spring located in the southwestern area of Saudi Arabia, afforded, along with previously isolated compounds, the undescribed polyketides penicillactonin (1), penipyranicin D (4) and isopyrenulin B (5) and the undescribed meroterpenoid preaustinoid C (7). The structures of these compounds were elucidated based on data from mass spectrometry, 1D and 2D NMR, and comparison between experimental and calculated ECD spectra. Penicillactonin and preaustinoid C bring unprecedented structural features, for which a biosynthetic rationale is proposed, further extending the chemodiversity associated to Penicillium fungi. Preaustinoid C showed significant activity against LPS-induced NO production and selective effect on IL-2 and IFN-γ gene regulation in activated Jurkat cells.

Penicillactonin and preaustinoid C, lactone-containing metabolites from a hot spring sediment Penicillium sp / Orfali, Raha; Perveen, Shagufta; Peng, Jiangnan; Alqahtani, Ali S; Nasr, Fahd A; Ahmed, Mohammad Z; Luciano, Paolo; Chianese, Giuseppina; Al-Taweel, Areej M; Taglialatela-Scafati, Orazio. - In: FITOTERAPIA. - ISSN 1873-6971. - 163:(2022), p. 105330. [10.1016/j.fitote.2022.105330]

Penicillactonin and preaustinoid C, lactone-containing metabolites from a hot spring sediment Penicillium sp

Luciano, Paolo
Methodology
;
Chianese, Giuseppina
Methodology
;
Taglialatela-Scafati, Orazio
Ultimo
Formal Analysis
2022

Abstract

Phytochemical investigation of Penicillium sp. RO-11 strain, collected from the sediments of a hydrothermal spring located in the southwestern area of Saudi Arabia, afforded, along with previously isolated compounds, the undescribed polyketides penicillactonin (1), penipyranicin D (4) and isopyrenulin B (5) and the undescribed meroterpenoid preaustinoid C (7). The structures of these compounds were elucidated based on data from mass spectrometry, 1D and 2D NMR, and comparison between experimental and calculated ECD spectra. Penicillactonin and preaustinoid C bring unprecedented structural features, for which a biosynthetic rationale is proposed, further extending the chemodiversity associated to Penicillium fungi. Preaustinoid C showed significant activity against LPS-induced NO production and selective effect on IL-2 and IFN-γ gene regulation in activated Jurkat cells.
2022
Penicillactonin and preaustinoid C, lactone-containing metabolites from a hot spring sediment Penicillium sp / Orfali, Raha; Perveen, Shagufta; Peng, Jiangnan; Alqahtani, Ali S; Nasr, Fahd A; Ahmed, Mohammad Z; Luciano, Paolo; Chianese, Giuseppina; Al-Taweel, Areej M; Taglialatela-Scafati, Orazio. - In: FITOTERAPIA. - ISSN 1873-6971. - 163:(2022), p. 105330. [10.1016/j.fitote.2022.105330]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/897522
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