Phytochemical investigation of Penicillium sp. RO-11 strain, collected from the sediments of a hydrothermal spring located in the southwestern area of Saudi Arabia, afforded, along with previously isolated compounds, the undescribed polyketides penicillactonin (1), penipyranicin D (4) and isopyrenulin B (5) and the undescribed meroterpenoid preaustinoid C (7). The structures of these compounds were elucidated based on data from mass spectrometry, 1D and 2D NMR, and comparison between experimental and calculated ECD spectra. Penicillactonin and preaustinoid C bring unprecedented structural features, for which a biosynthetic rationale is proposed, further extending the chemodiversity associated to Penicillium fungi. Preaustinoid C showed significant activity against LPS-induced NO production and selective effect on IL-2 and IFN-γ gene regulation in activated Jurkat cells.
Penicillactonin and preaustinoid C, lactone-containing metabolites from a hot spring sediment Penicillium sp / Orfali, R., Perveen, S., Peng, J., Alqahtani, A.S., Nasr, F.A., Ahmed, M.Z., Luciano, P., Chianese, G., Al-Taweel, A.M., Taglialatela-Scafati, O.. - In: FITOTERAPIA. - ISSN 1873-6971. - 163:(2022), p. 105330. [10.1016/j.fitote.2022.105330]
Penicillactonin and preaustinoid C, lactone-containing metabolites from a hot spring sediment Penicillium sp
Luciano, PaoloMethodology
;Chianese, GiuseppinaMethodology
;Taglialatela-Scafati, Orazio
Ultimo
Formal Analysis
2022
Abstract
Phytochemical investigation of Penicillium sp. RO-11 strain, collected from the sediments of a hydrothermal spring located in the southwestern area of Saudi Arabia, afforded, along with previously isolated compounds, the undescribed polyketides penicillactonin (1), penipyranicin D (4) and isopyrenulin B (5) and the undescribed meroterpenoid preaustinoid C (7). The structures of these compounds were elucidated based on data from mass spectrometry, 1D and 2D NMR, and comparison between experimental and calculated ECD spectra. Penicillactonin and preaustinoid C bring unprecedented structural features, for which a biosynthetic rationale is proposed, further extending the chemodiversity associated to Penicillium fungi. Preaustinoid C showed significant activity against LPS-induced NO production and selective effect on IL-2 and IFN-γ gene regulation in activated Jurkat cells.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
