The synthesis and characterization of a small series of cyclic triimidazole derivatives functionalized with methylated pyridine or guanidine moieties is reported. These compounds were tested for their ability to bind to G-quadruplexes from both telomeric and oncogene promoter sequences. Some of them exhibited high affinity and effective G-quadruplex-stabilizing properties. Overall, these compounds may represent useful leads for developing more potent and selective analogues.
Cyclic Triimidazoles as Stabilizers for Gene Promoter and Human Telomeric DNA G-Quadruplexes / Malpicci, D.; Andolina, S.; Di Ciolo, S.; Lucenti, E.; Cariati, E.; Marzano, S.; Pagano, B.; Amato, J.; Randazzo, A.; Giannini, C.. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1099-0690. - 2022:35(2022), p. e202200718. [10.1002/ejoc.202200718]
Cyclic Triimidazoles as Stabilizers for Gene Promoter and Human Telomeric DNA G-Quadruplexes
Cariati E.;Marzano S.;Pagano B.;Amato J.;Randazzo A.;
2022
Abstract
The synthesis and characterization of a small series of cyclic triimidazole derivatives functionalized with methylated pyridine or guanidine moieties is reported. These compounds were tested for their ability to bind to G-quadruplexes from both telomeric and oncogene promoter sequences. Some of them exhibited high affinity and effective G-quadruplex-stabilizing properties. Overall, these compounds may represent useful leads for developing more potent and selective analogues.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
