We demonstrate that several key aspects of the contractile activity of a cell interacting with the substrate can be captured by means of a non linear elastic tensegrity mechanical system made of a tensile element in parallel with a buckling-prone component, and exchanging forces with the surroundings through an extracellular matrix-focal adhesion complex. Mechanosensitivity of the focal adhesion plaque is triggered by pre-strain-driven buckling of the system induced either by pre-contraction or pre-polymerization of the constituents. The impact of pre-polymerization on the mechanical force and the implications of using linear and nonlinear elasticity for the focal adhesion plaque are assessed.
Pre-strains and buckling in mechanosensitivity of contractile cells and focal adhesions: A tensegrity model / Benvenuti, E; Reho, G A; Palumbo, S; Fraldi, M. - In: JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS. - ISSN 1751-6161. - 135:(2022), p. 105413. [10.1016/j.jmbbm.2022.105413]
Pre-strains and buckling in mechanosensitivity of contractile cells and focal adhesions: A tensegrity model
Palumbo, S;Fraldi, M
2022
Abstract
We demonstrate that several key aspects of the contractile activity of a cell interacting with the substrate can be captured by means of a non linear elastic tensegrity mechanical system made of a tensile element in parallel with a buckling-prone component, and exchanging forces with the surroundings through an extracellular matrix-focal adhesion complex. Mechanosensitivity of the focal adhesion plaque is triggered by pre-strain-driven buckling of the system induced either by pre-contraction or pre-polymerization of the constituents. The impact of pre-polymerization on the mechanical force and the implications of using linear and nonlinear elasticity for the focal adhesion plaque are assessed.File | Dimensione | Formato | |
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