Introduction. This study aimed to estimate the incidence of SARS-CoV-2 infection among pregnant women during the first pandemic wave in Italy, and to describe CO-VID-19 disease characteristics and maternal and perinatal outcomes. Materials and methods. National population-based prospective cohort study collecting information on women with SARS-CoV-2 diagnosis, confirmed within 7 days from hospital admission. Results. The national SARS-CoV-2 rate was 6.04 per 1,000 births (95% CI 5.62-6.49) among pregnant women and 7.54 (95% CI 7.47-7.61) among women in reproductive age. 72.1% of the cohort developed mild COVID-19 disease without pneumonia nor need for ventilatory support. Severe disease was significantly associated with women’s previous comorbidities (OR 2.55; 95% CI 0.98-6.90), obesity (OR 4.76; 95% CI 1.79-12.66) and citizenship from High Migration Pressure Countries (OR 3.43; 95% CI 1.27-9.25). Conclusions. During the first pandemic wave in Italy, the SARS-CoV-2 rate among pregnant women was lower compared to that detected among women of reproductive age, and risks of severe COVID-19 disease and adverse maternal and perinatal outcomes were rare.

The first SARS-CoV-2 wave among pregnant women in Italy: results from a prospective population-based study / Donati, S.; Corsi, E.; Maraschini, A.; Salvatore, M. A.; Baltaro, F.; Boldrini, R.; Bonassisa, S.; Brunelli, R.; Cagnacci, A.; Casucci, P.; Cataneo, I.; Cetin, I.; de Ambrosi, E.; Manso, M. D.; Fabiani, M.; Fieni, S.; Franchi, M. P.; Iurlaro, E.; Leo, L.; Liberati, M.; Sacchi, L. L.; Livio, S.; Locci, M.; Marozio, L.; Martini, C.; Maso, G.; Mecacci, F.; Meloni, A.; Mignuoli, A. D.; Moresi, S.; Patane, L.; Perotti, F.; Perrone, E.; Prefumo, F.; Ramenghi, L.; Rusciani, R.; Savasi, V.; Schettini, S. C. A.; Simeone, D.; Soligo, M.; Steinkasserer, M.; Tateo, S.; Ternelli, G.; Tironi, R.; Trojano, V.; Vergani, P.. - In: ANNALI DELL'ISTITUTO SUPERIORE DI SANITÀ. - ISSN 0021-2571. - 57:4(2021), pp. 272-285. [10.4415/ANN_21_04_02]

The first SARS-CoV-2 wave among pregnant women in Italy: results from a prospective population-based study

Locci M.;
2021

Abstract

Introduction. This study aimed to estimate the incidence of SARS-CoV-2 infection among pregnant women during the first pandemic wave in Italy, and to describe CO-VID-19 disease characteristics and maternal and perinatal outcomes. Materials and methods. National population-based prospective cohort study collecting information on women with SARS-CoV-2 diagnosis, confirmed within 7 days from hospital admission. Results. The national SARS-CoV-2 rate was 6.04 per 1,000 births (95% CI 5.62-6.49) among pregnant women and 7.54 (95% CI 7.47-7.61) among women in reproductive age. 72.1% of the cohort developed mild COVID-19 disease without pneumonia nor need for ventilatory support. Severe disease was significantly associated with women’s previous comorbidities (OR 2.55; 95% CI 0.98-6.90), obesity (OR 4.76; 95% CI 1.79-12.66) and citizenship from High Migration Pressure Countries (OR 3.43; 95% CI 1.27-9.25). Conclusions. During the first pandemic wave in Italy, the SARS-CoV-2 rate among pregnant women was lower compared to that detected among women of reproductive age, and risks of severe COVID-19 disease and adverse maternal and perinatal outcomes were rare.
2021
The first SARS-CoV-2 wave among pregnant women in Italy: results from a prospective population-based study / Donati, S.; Corsi, E.; Maraschini, A.; Salvatore, M. A.; Baltaro, F.; Boldrini, R.; Bonassisa, S.; Brunelli, R.; Cagnacci, A.; Casucci, P.; Cataneo, I.; Cetin, I.; de Ambrosi, E.; Manso, M. D.; Fabiani, M.; Fieni, S.; Franchi, M. P.; Iurlaro, E.; Leo, L.; Liberati, M.; Sacchi, L. L.; Livio, S.; Locci, M.; Marozio, L.; Martini, C.; Maso, G.; Mecacci, F.; Meloni, A.; Mignuoli, A. D.; Moresi, S.; Patane, L.; Perotti, F.; Perrone, E.; Prefumo, F.; Ramenghi, L.; Rusciani, R.; Savasi, V.; Schettini, S. C. A.; Simeone, D.; Soligo, M.; Steinkasserer, M.; Tateo, S.; Ternelli, G.; Tironi, R.; Trojano, V.; Vergani, P.. - In: ANNALI DELL'ISTITUTO SUPERIORE DI SANITÀ. - ISSN 0021-2571. - 57:4(2021), pp. 272-285. [10.4415/ANN_21_04_02]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/895539
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