Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that enhance the immune response against cancer cells. ICIs are generally well tolerated, although endocrine immune-related adverse events (irAEs) are common. We investigated the risk factors for thyroid irAEs in patients treated with ICIs. Moreover, we evaluated the clinical outcome of subjects who became hypothyroid compared to euthyroid patients.

Higher baseline TSH levels predict early hypothyroidism during cancer immunotherapy / Luongo, C; Morra, R; Gambale, C; Porcelli, T; Sessa, F; Matano, E; Damiano, V; Klain, M; Schlumberger, M; Salvatore, D. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 1720-8386. - 44:9(2021), pp. 1927-1933. [10.1007/s40618-021-01508-5]

Higher baseline TSH levels predict early hypothyroidism during cancer immunotherapy

Luongo, C;Morra, R;Gambale, C;Porcelli, T;Sessa, F;Matano, E;Damiano, V;Klain, M;Salvatore, D
2021

Abstract

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that enhance the immune response against cancer cells. ICIs are generally well tolerated, although endocrine immune-related adverse events (irAEs) are common. We investigated the risk factors for thyroid irAEs in patients treated with ICIs. Moreover, we evaluated the clinical outcome of subjects who became hypothyroid compared to euthyroid patients.
2021
Higher baseline TSH levels predict early hypothyroidism during cancer immunotherapy / Luongo, C; Morra, R; Gambale, C; Porcelli, T; Sessa, F; Matano, E; Damiano, V; Klain, M; Schlumberger, M; Salvatore, D. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 1720-8386. - 44:9(2021), pp. 1927-1933. [10.1007/s40618-021-01508-5]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/894751
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