Rare-earth elements are emerging contaminants of soil and water bodies which destiny in the environment and effects on organisms is modulated by their interactions with natural ligands produced by bacteria, fungi and plants. Within this framework, coordination by harzianic acid (H2L), a Trichoderma secondary metabolite, of a selection of tripositive rare-earth cations Ln3+ (Ln3+ = La3+, Nd3+, Sm3+, and Gd3+) was investigated at 25 °C, and in a CH3OH/0.1 M NaClO4 (50/50 w/w) solvent, using mass spectrometry, circular dichroism, UV-Vis spectrophotometry, and pH measurements. Experimental data can be satisfactorily explained by assuming, for all investigated cations, the formation of a mono-complex (LnL+) and a bis-complex (LnL2-). Differences were found between the formation constants of complexes of different Ln3+ cations, which can be correlated with ionic radius. Since gadolinium is the element that raises the most concern among lanthanide elements, its effects on organisms at different levels of biological organization were explored, in the presence and absence of harzianic acid. Results of ecotoxicological tests suggest that harzianic acid can decrease gadolinium biotoxicity, presumably because of complex formation with Gd3+.

Interaction of the Fungal Metabolite Harzianic Acid with Rare-Earth Cations (La3+, Nd3+, Sm3+, Gd3+) / De Tommaso, Gaetano; Salvatore, Maria Michela; Siciliano, Antonietta; Staropoli, Alessia; Vinale, Francesco; Nicoletti, Rosario; Della Greca, Marina; Guida, Marco; Salvatore, Francesco; Iuliano, Mauro; Andolfi, Anna. - In: MOLECULES. - ISSN 1420-3049. - 27:6(2022), p. 1959. [10.3390/molecules27061959]

Interaction of the Fungal Metabolite Harzianic Acid with Rare-Earth Cations (La3+, Nd3+, Sm3+, Gd3+)

De Tommaso, Gaetano
Co-primo
;
Salvatore, Maria Michela
Co-primo
;
Siciliano, Antonietta;Staropoli, Alessia;Vinale, Francesco;Della Greca, Marina;Guida, Marco;Salvatore, Francesco
;
Iuliano, Mauro
;
Andolfi, Anna
Ultimo
2022

Abstract

Rare-earth elements are emerging contaminants of soil and water bodies which destiny in the environment and effects on organisms is modulated by their interactions with natural ligands produced by bacteria, fungi and plants. Within this framework, coordination by harzianic acid (H2L), a Trichoderma secondary metabolite, of a selection of tripositive rare-earth cations Ln3+ (Ln3+ = La3+, Nd3+, Sm3+, and Gd3+) was investigated at 25 °C, and in a CH3OH/0.1 M NaClO4 (50/50 w/w) solvent, using mass spectrometry, circular dichroism, UV-Vis spectrophotometry, and pH measurements. Experimental data can be satisfactorily explained by assuming, for all investigated cations, the formation of a mono-complex (LnL+) and a bis-complex (LnL2-). Differences were found between the formation constants of complexes of different Ln3+ cations, which can be correlated with ionic radius. Since gadolinium is the element that raises the most concern among lanthanide elements, its effects on organisms at different levels of biological organization were explored, in the presence and absence of harzianic acid. Results of ecotoxicological tests suggest that harzianic acid can decrease gadolinium biotoxicity, presumably because of complex formation with Gd3+.
2022
Interaction of the Fungal Metabolite Harzianic Acid with Rare-Earth Cations (La3+, Nd3+, Sm3+, Gd3+) / De Tommaso, Gaetano; Salvatore, Maria Michela; Siciliano, Antonietta; Staropoli, Alessia; Vinale, Francesco; Nicoletti, Rosario; Della Greca, Marina; Guida, Marco; Salvatore, Francesco; Iuliano, Mauro; Andolfi, Anna. - In: MOLECULES. - ISSN 1420-3049. - 27:6(2022), p. 1959. [10.3390/molecules27061959]
File in questo prodotto:
File Dimensione Formato  
Interaction of the Fungal Metabolite Harzianic Acid with.pdf

solo utenti autorizzati

Licenza: Accesso privato/ristretto
Dimensione 813.85 kB
Formato Adobe PDF
813.85 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/891675
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 3
social impact