Imprinting Control Regions (ICRs) are CpG-rich sequences acquiring differential methylation in the female and male germline and maintaining it in a parental origin-specific manner in somatic cells. Despite their expected high mutation rate due to spontaneous deamination of methylated cytosines, ICRs show conservation of CpG-richness and CpG-containing transcription factor binding sites in mammalian species. However, little is known about the mechanisms contributing to the maintenance of a high density of methyl CpGs at these loci.
The mismatch-repair proteins MSH2 and MSH6 interact with the imprinting control regions through the ZFP57-KAP1 complex / Acurzio, Basilia; Cecere, Francesco; Giaccari, Carlo; Verma, Ankit; Russo, Rosita; Valletta, Mariangela; Hay Mele, Bruno; Angelini, Claudia; Chambery, Angela; Riccio, Andrea. - In: EPIGENETICS & CHROMATIN. - ISSN 1756-8935. - 15:1(2022), p. 27. [10.1186/s13072-022-00462-7]
The mismatch-repair proteins MSH2 and MSH6 interact with the imprinting control regions through the ZFP57-KAP1 complex
Acurzio, BasiliaPrimo
;Hay Mele, Bruno;
2022
Abstract
Imprinting Control Regions (ICRs) are CpG-rich sequences acquiring differential methylation in the female and male germline and maintaining it in a parental origin-specific manner in somatic cells. Despite their expected high mutation rate due to spontaneous deamination of methylated cytosines, ICRs show conservation of CpG-richness and CpG-containing transcription factor binding sites in mammalian species. However, little is known about the mechanisms contributing to the maintenance of a high density of methyl CpGs at these loci.| File | Dimensione | Formato | |
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