Cellular senescence, an irreversible proliferative cell arrest, is caused by excessive intracellular or extracellular stress/damage. Increased senescent cells have been identified in multiple tissues in different metabolic and other aging-related diseases. Recently, several human and mouse studies emphasized the involvement of senescence in development and progression of NAFLD. Hyperinsulinemia, seen in obesity, metabolic syndrome, and other conditions of insulin resistance, has been linked to senescence in adipocytes and neurons. Here, we investigate the possible direct role of chronic hyperinsulinemia in the development of senescence in human hepatocytes.
Chronic hyperinsulinemia promotes human hepatocyte senescence / Baboota, Ritesh K; Spinelli, Rosa; Erlandsson, Malin C; Brandao, Bruna B; Lino, Marsel; Yang, Hong; Mardinoglu, Adil; Bokarewa, Maria I; Boucher, Jeremie; Kahn, C Ronald; Smith, Ulf. - In: MOLECULAR METABOLISM. - ISSN 2212-8778. - (2022), p. 101558. [10.1016/j.molmet.2022.101558]
Chronic hyperinsulinemia promotes human hepatocyte senescence
Spinelli, RosaSecondo
;
2022
Abstract
Cellular senescence, an irreversible proliferative cell arrest, is caused by excessive intracellular or extracellular stress/damage. Increased senescent cells have been identified in multiple tissues in different metabolic and other aging-related diseases. Recently, several human and mouse studies emphasized the involvement of senescence in development and progression of NAFLD. Hyperinsulinemia, seen in obesity, metabolic syndrome, and other conditions of insulin resistance, has been linked to senescence in adipocytes and neurons. Here, we investigate the possible direct role of chronic hyperinsulinemia in the development of senescence in human hepatocytes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
