A fine-tuned balance of glucocorticoid receptor (GR) activation is essential for organ formation, with disturbances influencing many health outcomes. In utero, glucocorticoids have been linked to brain-related negative outcomes, with unclear underlying mechanisms, especially regarding cell-type-specific effects. An in vitro model of fetal human brain development, induced human pluripotent stem cell (hiPSC)-derived cerebral organoids, was used to test whether cerebral organoids are suitable for studying the impact of prenatal glucocorticoid exposure on the developing brain.

Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study / Cruceanu, C., Dony, L., Krontira, A.c., Fischer, D.s., Roeh, S., Di Giaimo, R., Kyrousi, C., Kaspar, L., Arloth, J., Czamara, D., Gerstner, N., Martinelli, S., Wehner, S., Breen, M.s., Koedel, M., Sauer, S., Sportelli, V., Rex-Haffner, M., Cappello, S., Theis, F.j., et al.. - In: THE AMERICAN JOURNAL OF PSYCHIATRY. - ISSN 1535-7228. - 179:5(2022), pp. 375-387. [10.1176/appi.ajp.2021.21010095]

Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study

Di Giaimo R;
2022

Abstract

A fine-tuned balance of glucocorticoid receptor (GR) activation is essential for organ formation, with disturbances influencing many health outcomes. In utero, glucocorticoids have been linked to brain-related negative outcomes, with unclear underlying mechanisms, especially regarding cell-type-specific effects. An in vitro model of fetal human brain development, induced human pluripotent stem cell (hiPSC)-derived cerebral organoids, was used to test whether cerebral organoids are suitable for studying the impact of prenatal glucocorticoid exposure on the developing brain.
2022
Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study / Cruceanu, C., Dony, L., Krontira, A.c., Fischer, D.s., Roeh, S., Di Giaimo, R., Kyrousi, C., Kaspar, L., Arloth, J., Czamara, D., Gerstner, N., Martinelli, S., Wehner, S., Breen, M.s., Koedel, M., Sauer, S., Sportelli, V., Rex-Haffner, M., Cappello, S., Theis, F.j., et al.. - In: THE AMERICAN JOURNAL OF PSYCHIATRY. - ISSN 1535-7228. - 179:5(2022), pp. 375-387. [10.1176/appi.ajp.2021.21010095]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/891106
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