A fine-tuned balance of glucocorticoid receptor (GR) activation is essential for organ formation, with disturbances influencing many health outcomes. In utero, glucocorticoids have been linked to brain-related negative outcomes, with unclear underlying mechanisms, especially regarding cell-type-specific effects. An in vitro model of fetal human brain development, induced human pluripotent stem cell (hiPSC)-derived cerebral organoids, was used to test whether cerebral organoids are suitable for studying the impact of prenatal glucocorticoid exposure on the developing brain.
Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study / Cruceanu, C; Dony, L; Krontira, Ac; Fischer, Ds; Roeh, S; Di Giaimo, R; Kyrousi, C; Kaspar, L; Arloth, J; Czamara, D; Gerstner, N; Martinelli, S; Wehner, S; Breen, Ms; Koedel, M; Sauer, S; Sportelli, V; Rex-Haffner, M; Cappello, S; Theis, Fj; Binder, Eb.. - In: THE AMERICAN JOURNAL OF PSYCHIATRY. - ISSN 1535-7228. - 179:5(2022), pp. 375-387. [10.1176/appi.ajp.2021.21010095]
Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study
Di Giaimo R;
2022
Abstract
A fine-tuned balance of glucocorticoid receptor (GR) activation is essential for organ formation, with disturbances influencing many health outcomes. In utero, glucocorticoids have been linked to brain-related negative outcomes, with unclear underlying mechanisms, especially regarding cell-type-specific effects. An in vitro model of fetal human brain development, induced human pluripotent stem cell (hiPSC)-derived cerebral organoids, was used to test whether cerebral organoids are suitable for studying the impact of prenatal glucocorticoid exposure on the developing brain.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
