Aromatase inhibitors versus tamoxifen in premenopausal women with oestrogen receptor-positive early-stage breast cancer treated with ovarian suppression: a patient-level meta-analysis of 7030 women from four randomised trials

Bradley, R.; Braybrooke, J.; Gray, R.; Hills, R. K.; Liu, Z.; Pan, H.; Peto, R.; Dodwell, D.; Mcgale, P.; Taylor, C.; Francis, P. A.; Gnant, M.; Perrone, F.; Regan, M. M.; Berry, R.; Boddington, C.; Clarke, M.; Davies, C.; Davies, L.; Duane, F.; Evans, V.; Gay, J.; Gettins, L.; Godwin, J.; James, S.; Liu, H.; Mackinnon, E.; Mannu, G.; Mchugh, T.; Morris, P.; Read, S.; Straiton, E.; Jakesz, R.; Fesl, C.; Pagani, O.; Gelber, R.; De Laurentiis, M.; De Placido, S.; Gallo, C.; Albain, K.; Anderson, S.; Arriagada, R.; Bartlett, J.; Bergsten-Nordstrom, E.; Bliss, J.; Brain, E.; Carey, L.; Coleman, R.; Cuzick, J.; Davidson, N.; Del Mastro, L.; Di Leo, A.; Dignam, J.; Dowsett, M.; Ejlertsen, B.; Goetz, M.; Goodwin, P.; Halpin-Murphy, P.; Hayes, D.; Hill, C.; Jagsi, R.; Janni, W.; Loibl, S.; Mamounas, E. P.; Martin, M.; Mukai, H.; Nekljudova, V.; Norton, L.; Ohashi, Y.; Pierce, L.; Poortmans, P.; Pritchard, K. I.; Raina, V.; Rea, D.; Robertson, J.; Rutgers, E.; Spanic, T.; Sparano, J.; Steger, G.; Tang, G.; Toi, M.; Tutt, A.; Viale, G.; Wang, X.; Whelan, T.; Wilcken, N.; Wolmark, N.; Cameron, D.; Bergh, J.; Swain, S. M.

doi:10.1016/S1470-2045(21)00758-0

For women with early-stage oestrogen receptor (ER)-positive breast cancer, adjuvant tamoxifen reduces 15-year breast cancer mortality by a third. Aromatase inhibitors are more effective than tamoxifen in postmenopausal women but are ineffective in premenopausal women when used without ovarian suppression. We aimed to investigate whether premenopausal women treated with ovarian suppression benefit from aromatase inhibitors.

Aromatase inhibitors versus tamoxifen in premenopausal women with oestrogen receptor-positive early-stage breast cancer treated with ovarian suppression: a patient-level meta-analysis of 7030 women from four randomised trials / Bradley, R.; Braybrooke, J.; Gray, R.; Hills, R. K.; Liu, Z.; Pan, H.; Peto, R.; Dodwell, D.; Mcgale, P.; Taylor, C.; Francis, P. A.; Gnant, M.; Perrone, F.; Regan, M. M.; Berry, R.; Boddington, C.; Clarke, M.; Davies, C.; Davies, L.; Duane, F.; Evans, V.; Gay, J.; Gettins, L.; Godwin, J.; James, S.; Liu, H.; Mackinnon, E.; Mannu, G.; Mchugh, T.; Morris, P.; Read, S.; Straiton, E.; Jakesz, R.; Fesl, C.; Pagani, O.; Gelber, R.; De Laurentiis, M.; De Placido, S.; Gallo, C.; Albain, K.; Anderson, S.; Arriagada, R.; Bartlett, J.; Bergsten-Nordstrom, E.; Bliss, J.; Brain, E.; Carey, L.; Coleman, R.; Cuzick, J.; Davidson, N.; Del Mastro, L.; Di Leo, A.; Dignam, J.; Dowsett, M.; Ejlertsen, B.; Goetz, M.; Goodwin, P.; Halpin-Murphy, P.; Hayes, D.; Hill, C.; Jagsi, R.; Janni, W.; Loibl, S.; Mamounas, E. P.; Martin, M.; Mukai, H.; Nekljudova, V.; Norton, L.; Ohashi, Y.; Pierce, L.; Poortmans, P.; Pritchard, K. I.; Raina, V.; Rea, D.; Robertson, J.; Rutgers, E.; Spanic, T.; Sparano, J.; Steger, G.; Tang, G.; Toi, M.; Tutt, A.; Viale, G.; Wang, X.; Whelan, T.; Wilcken, N.; Wolmark, N.; Cameron, D.; Bergh, J.; Swain, S. M.. - In: THE LANCET ONCOLOGY. - ISSN 1474-5488. - 23:3(2022), pp. 382-392. [10.1016/S1470-2045(21)00758-0]