Peptide T (PT), an octapeptide fragment located in the V2 region of the HIV-1 gp120-coating protein, appears to be beneficial in the treatment of psoriasis. Our previous investigations suggest that keratinocytes play a key role in conditioning the therapeutic effects of PT in psoriasis. The aim of this study was to explore the effects of PT and the peptidomimetic natural products, Dhurrin and Prunasin, on the expression of the IL-6, IL-8, IL-23, HSP70 and ICAM-1 on IFN-gamma and TNF-alpha-NHEK activated cells. Moreover, we analysed the interference of PT and its analogues through STAT-3 activation. Our results show that the analogues tested exhibit the beneficial biological effects of PT, suggesting the primary role of keratinocytes upon which PT and the peptidomimetics act directly, by reducing proinflammatory responses. Its reduction appears to be important for therapeutic approach in psoriasis pathogenesis.

Amygdalin Analogues Inhibit IFN-gamma Signalling and Reduce the Inflammatory Response in Human Epidermal Keratinocytes / Paoletti, I; De Gregorio, V; Baroni, A; Tufano, Ma; Donnarumma, G; Perez, Jj. - In: INFLAMMATION. - ISSN 0360-3997. - 36:6(2013), pp. 1316-1326. [10.1007/s10753-013-9670-7]

Amygdalin Analogues Inhibit IFN-gamma Signalling and Reduce the Inflammatory Response in Human Epidermal Keratinocytes

De Gregorio V
Co-primo
;
2013

Abstract

Peptide T (PT), an octapeptide fragment located in the V2 region of the HIV-1 gp120-coating protein, appears to be beneficial in the treatment of psoriasis. Our previous investigations suggest that keratinocytes play a key role in conditioning the therapeutic effects of PT in psoriasis. The aim of this study was to explore the effects of PT and the peptidomimetic natural products, Dhurrin and Prunasin, on the expression of the IL-6, IL-8, IL-23, HSP70 and ICAM-1 on IFN-gamma and TNF-alpha-NHEK activated cells. Moreover, we analysed the interference of PT and its analogues through STAT-3 activation. Our results show that the analogues tested exhibit the beneficial biological effects of PT, suggesting the primary role of keratinocytes upon which PT and the peptidomimetics act directly, by reducing proinflammatory responses. Its reduction appears to be important for therapeutic approach in psoriasis pathogenesis.
2013
Amygdalin Analogues Inhibit IFN-gamma Signalling and Reduce the Inflammatory Response in Human Epidermal Keratinocytes / Paoletti, I; De Gregorio, V; Baroni, A; Tufano, Ma; Donnarumma, G; Perez, Jj. - In: INFLAMMATION. - ISSN 0360-3997. - 36:6(2013), pp. 1316-1326. [10.1007/s10753-013-9670-7]
File in questo prodotto:
File Dimensione Formato  
14. Paoletti2013_Article_AmygdalinAnaloguesInhibitIFN-γ.pdf

non disponibili

Tipologia: Versione Editoriale (PDF)
Licenza: Non specificato
Dimensione 516.23 kB
Formato Adobe PDF
516.23 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/890523
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 23
  • ???jsp.display-item.citation.isi??? 21
social impact