We evaluated the impact of liposomal doxorubicin (NPLD) supercharge-containing therapy on interim fluorodeoxyglucose positron emission tomography (interim-FDG-PET) responses in high-risk diffuse large B-cell lymphoma (DLBCL) or classical Hodgkin lymphoma (c-HL). In this phase II study (2016-2021), 81 adult patients with advanced-stage DLBCL (n = 53) and c-HL (n = 28) received front-line treatment with R-COMP-dose-intensified (DI) and MBVD-DI. R-COMP-DI consisted of 70 mg/m2 of NPLD plus standard rituximab, cyclophosphamide, vincristine and prednisone for three cycles (followed by three cycles with NPLD de-escalated at 50 mg/m2 ); MBVD-DI consisted of 35 mg/m2 of NPLD plus standard bleomycin, vinblastine and dacarbazine for two cycles (followed by four cycles with NPLD de-escalated at 25 mg/m2 ). Patients underwent R-COMP-DI and MBVD-DI with a median dose intensity of 91% and 94% respectively. At interim-FDG-PET, 72/81 patients (one failed to undergo interim-FDG-PET due to early death) had a Deauville score of ≤3. At end of treatment, 90% of patients reached complete responses. In all, 20 patients had Grade ≥3 adverse events, and four of them required hospitalisation. At a median 21-months of follow-up, the progression-free survival of the entire population was 77.3% (95% confidence interval 68%-88%). Our data suggest that the NPLD supercharge-driven strategy in high-risk DLBCL/c-HL may be a promising option to test in phase III trials, for improving negative interim-FDG-PET cases incidence.

Liposomal doxorubicin supercharge-containing front-line treatment in patients with advanced-stage diffuse large B-cell lymphoma or classical Hodgkin lymphoma: Preliminary results of a single-centre phase II study / Picardi, Marco; Giordano, Claudia; Pugliese, Novella; Esposito, Maria; Fatigati, Melania; Muriano, Francesco; Rascato, Maria G; Pepa, Roberta Della; D'Ambrosio, Alessandro; Vigliar, Elena; Troncone, Giancarlo; Russo, Daniela; Mascolo, Massimo; Esposito, Giovanni; Prastaro, Mariella; Esposito, Roberta; Tocchetti, Carlo G; Fonti, Rosa; Mainolfi, Ciro; Del Vecchio, Silvana; Pane, Fabrizio. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - (2022). [10.1111/bjh.18348]

Liposomal doxorubicin supercharge-containing front-line treatment in patients with advanced-stage diffuse large B-cell lymphoma or classical Hodgkin lymphoma: Preliminary results of a single-centre phase II study

Picardi, Marco;Giordano, Claudia
;
Pugliese, Novella;Muriano, Francesco;Rascato, Maria G;Pepa, Roberta Della;Vigliar, Elena;Troncone, Giancarlo;Russo, Daniela;Mascolo, Massimo;Esposito, Giovanni;Esposito, Roberta;Tocchetti, Carlo G;Fonti, Rosa;Mainolfi, Ciro;Del Vecchio, Silvana;Pane, Fabrizio
2022

Abstract

We evaluated the impact of liposomal doxorubicin (NPLD) supercharge-containing therapy on interim fluorodeoxyglucose positron emission tomography (interim-FDG-PET) responses in high-risk diffuse large B-cell lymphoma (DLBCL) or classical Hodgkin lymphoma (c-HL). In this phase II study (2016-2021), 81 adult patients with advanced-stage DLBCL (n = 53) and c-HL (n = 28) received front-line treatment with R-COMP-dose-intensified (DI) and MBVD-DI. R-COMP-DI consisted of 70 mg/m2 of NPLD plus standard rituximab, cyclophosphamide, vincristine and prednisone for three cycles (followed by three cycles with NPLD de-escalated at 50 mg/m2 ); MBVD-DI consisted of 35 mg/m2 of NPLD plus standard bleomycin, vinblastine and dacarbazine for two cycles (followed by four cycles with NPLD de-escalated at 25 mg/m2 ). Patients underwent R-COMP-DI and MBVD-DI with a median dose intensity of 91% and 94% respectively. At interim-FDG-PET, 72/81 patients (one failed to undergo interim-FDG-PET due to early death) had a Deauville score of ≤3. At end of treatment, 90% of patients reached complete responses. In all, 20 patients had Grade ≥3 adverse events, and four of them required hospitalisation. At a median 21-months of follow-up, the progression-free survival of the entire population was 77.3% (95% confidence interval 68%-88%). Our data suggest that the NPLD supercharge-driven strategy in high-risk DLBCL/c-HL may be a promising option to test in phase III trials, for improving negative interim-FDG-PET cases incidence.
2022
Liposomal doxorubicin supercharge-containing front-line treatment in patients with advanced-stage diffuse large B-cell lymphoma or classical Hodgkin lymphoma: Preliminary results of a single-centre phase II study / Picardi, Marco; Giordano, Claudia; Pugliese, Novella; Esposito, Maria; Fatigati, Melania; Muriano, Francesco; Rascato, Maria G; Pepa, Roberta Della; D'Ambrosio, Alessandro; Vigliar, Elena; Troncone, Giancarlo; Russo, Daniela; Mascolo, Massimo; Esposito, Giovanni; Prastaro, Mariella; Esposito, Roberta; Tocchetti, Carlo G; Fonti, Rosa; Mainolfi, Ciro; Del Vecchio, Silvana; Pane, Fabrizio. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - (2022). [10.1111/bjh.18348]
File in questo prodotto:
File Dimensione Formato  
Br J Haematol - 2022 - Picardi - Liposomal doxorubicin supercharge‐containing front‐line treatment in patients with.pdf

accesso aperto

Licenza: Creative commons
Dimensione 1.53 MB
Formato Adobe PDF
1.53 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/890440
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 7
social impact