: Phytochemical investigation of the aerial parts obtained from the Turkish plant Centaurea kotschyi subsp. persica led to the isolation of nine sesquiterpene lactones belonging to the guaiane class, including the undescribed kotschyols A and B, a monoterpene lactone (daphnauranin E), four known lignans (matairesinol, matairesinoside, arctiin and arctigenin) and an undescribed dihydrobenzofuran neolignan (4-O-glucosylcrataegifin A). The structures of these compounds were defined by spectroscopic analysis, including ECD and 1D/2D NMR, and chemical conversion. Spurred from the traditional use of C. kotschyi subsp. persica and previous reports on the activity of its extracts, the isolated compounds were evaluated for their hypoglycaemic activity disclosing the bioactive components.

Guaiane-rich phytochemical profile of Centaurea kotschyi subsp. persica (Boiss.) Wagenitz and identification of hypoglycaemic metabolites / Serino, Elena; Chianese, Giuseppina; Musto, Giorgia; Zengin, Gökhan; Rigano, Daniela; Stornaiuolo, Mariano; Formisano, Carmen; Taglialatela-Scafati, Orazio. - In: PHYTOCHEMISTRY. - ISSN 0031-9422. - 199:(2022), p. 113189. [10.1016/j.phytochem.2022.113189]

Guaiane-rich phytochemical profile of Centaurea kotschyi subsp. persica (Boiss.) Wagenitz and identification of hypoglycaemic metabolites

Serino, Elena
Primo
Investigation
;
Chianese, Giuseppina
Secondo
Investigation
;
Musto, Giorgia
Investigation
;
Rigano, Daniela
Membro del Collaboration Group
;
Stornaiuolo, Mariano
Formal Analysis
;
Formisano, Carmen
Penultimo
Formal Analysis
;
Taglialatela-Scafati, Orazio
Ultimo
Writing – Original Draft Preparation
2022

Abstract

: Phytochemical investigation of the aerial parts obtained from the Turkish plant Centaurea kotschyi subsp. persica led to the isolation of nine sesquiterpene lactones belonging to the guaiane class, including the undescribed kotschyols A and B, a monoterpene lactone (daphnauranin E), four known lignans (matairesinol, matairesinoside, arctiin and arctigenin) and an undescribed dihydrobenzofuran neolignan (4-O-glucosylcrataegifin A). The structures of these compounds were defined by spectroscopic analysis, including ECD and 1D/2D NMR, and chemical conversion. Spurred from the traditional use of C. kotschyi subsp. persica and previous reports on the activity of its extracts, the isolated compounds were evaluated for their hypoglycaemic activity disclosing the bioactive components.
2022
Guaiane-rich phytochemical profile of Centaurea kotschyi subsp. persica (Boiss.) Wagenitz and identification of hypoglycaemic metabolites / Serino, Elena; Chianese, Giuseppina; Musto, Giorgia; Zengin, Gökhan; Rigano, Daniela; Stornaiuolo, Mariano; Formisano, Carmen; Taglialatela-Scafati, Orazio. - In: PHYTOCHEMISTRY. - ISSN 0031-9422. - 199:(2022), p. 113189. [10.1016/j.phytochem.2022.113189]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/883667
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