Natural products and their synthetic analogs and derivatives are a traditional source of bioactive molecules with potential development as drug candidates. In this context, Marine Natural Products (MNPs) represent a rich reservoir of diverse molecular skeletons with potential pharmacological activity that, so far, has been mostly explored in cancer and infectious diseases. Starting from the development of a novel bioassay‐guided screening platform for immunomodulatory compounds from an in‐house MNPs library, we report the identification of the alkaloid lepadin A as a new model compound for immune‐based anticancer activity with characteristics that suggest a possible mechanism as Immunogenic Cell Death inducer. The work describes the molecular‐based bioprospecting in the Gulf of Naples together with the bioassay-guided fractionation, the chemical characterization of the alkaloid, and the biological activity in mouse dendritic cells (D1).
Identification of the Marine Alkaloid Lepadin A as Potential Inducer of Immunogenic Cell Death / Nuzzo, G., Gallo, C., Crocetta, F., Romano, L., Barra, G., Senese, G., Dell'Isola, M., Carbone, D., Tanduo, V., Albiani, F., Villani, G., D'Ippolito, G., Manzo, E., Fontana, A.. - In: BIOMOLECULES. - ISSN 2218-273X. - 12:2(2022), p. 246. [10.3390/biom12020246]
Identification of the Marine Alkaloid Lepadin A as Potential Inducer of Immunogenic Cell Death
Crocetta F.;dell'Isola M.;Carbone D.;Albiani F.;D'ippolito G.;Fontana A.
2022
Abstract
Natural products and their synthetic analogs and derivatives are a traditional source of bioactive molecules with potential development as drug candidates. In this context, Marine Natural Products (MNPs) represent a rich reservoir of diverse molecular skeletons with potential pharmacological activity that, so far, has been mostly explored in cancer and infectious diseases. Starting from the development of a novel bioassay‐guided screening platform for immunomodulatory compounds from an in‐house MNPs library, we report the identification of the alkaloid lepadin A as a new model compound for immune‐based anticancer activity with characteristics that suggest a possible mechanism as Immunogenic Cell Death inducer. The work describes the molecular‐based bioprospecting in the Gulf of Naples together with the bioassay-guided fractionation, the chemical characterization of the alkaloid, and the biological activity in mouse dendritic cells (D1).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
