This paper reports the study of terpene biosynthesis in the marine nudibranch Doriopsilla pelseneeri. In ViVo feeding experiments with 13C-glucose proved the de noVo origin of the terpene metabolites via a mevalonate pathway. Characterization of the stereochemical relationship of the new acetyl pelseneeriols (7 and 8) suggests a two-step mechanism for the sesquiterpene cyclization, leading to a slight refinement of terpene tailoring in this family of marine invertebrates.
Biosynthetic Evidence Supporting the Generation of Terpene ChemoDiversity in Marine Mollusks of the genus Doriopsilla / H., Gaspar; A., Cutignano; T., Ferreira; G., Calado; G., Cimino; Fontana, A. - In: JOURNAL OF NATURAL PRODUCTS. - ISSN 0163-3864. - 71:12(2008), pp. 2053-2056. [10.1021/np8004387]
Biosynthetic Evidence Supporting the Generation of Terpene ChemoDiversity in Marine Mollusks of the genus Doriopsilla
Fontana A
2008
Abstract
This paper reports the study of terpene biosynthesis in the marine nudibranch Doriopsilla pelseneeri. In ViVo feeding experiments with 13C-glucose proved the de noVo origin of the terpene metabolites via a mevalonate pathway. Characterization of the stereochemical relationship of the new acetyl pelseneeriols (7 and 8) suggests a two-step mechanism for the sesquiterpene cyclization, leading to a slight refinement of terpene tailoring in this family of marine invertebrates.| File | Dimensione | Formato | |
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