The investigation is related to the development of a general strategy for the synthesis of glycolipids including analogs bearing polyunsaturated fatty acids. In particular, here we report exceptionally mild and selective conditions to remove acetate protecting groups from glyceroglycolipids by hydrazinolysis. Synthetic 1,2-O-di-arachidonoyl-3-O-beta-galactosyl-glycerol was used as representative of polyunsaturated beta-galactosyl-di-acyl-glycerols due to its reactivity under the conditions usually employed in literature. (C) 2016 Elsevier Ltd. All rights reserved.
Glycolipids synthesis: improved hydrazinolysis conditions for preparation of 1,2-polyunsaturated fatty acyl-beta-monogalactosyl-glycerols / Pagano, Dario; Cutignano, Adele; Manzo, Emiliano; Tinto, Francesco; Fontana, A. - In: CARBOHYDRATE RESEARCH. - ISSN 0008-6215. - 424:(2016), pp. 21-23. [10.1016/j.carres.2016.02.005]
Glycolipids synthesis: improved hydrazinolysis conditions for preparation of 1,2-polyunsaturated fatty acyl-beta-monogalactosyl-glycerols
Fontana A
2016
Abstract
The investigation is related to the development of a general strategy for the synthesis of glycolipids including analogs bearing polyunsaturated fatty acids. In particular, here we report exceptionally mild and selective conditions to remove acetate protecting groups from glyceroglycolipids by hydrazinolysis. Synthetic 1,2-O-di-arachidonoyl-3-O-beta-galactosyl-glycerol was used as representative of polyunsaturated beta-galactosyl-di-acyl-glycerols due to its reactivity under the conditions usually employed in literature. (C) 2016 Elsevier Ltd. All rights reserved.| File | Dimensione | Formato | |
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