An efficient and versatile chemical synthesis of bioactive glyco-glycerolipids

Synthesis of b-glyco-1,2-diacylglycerols is achieved by a versatile and simple procedure based on trichloro-acetimidate methodology and use of peracetate sugar substrates. The chemical strategy was tested through stereoselective preparation of b-galacto- and b-gluco-lipid derivatives capable to trigger immune system response. The synthetic approach is designed to obtain enantiomerically pure regioand stereo-isomers including derivatives containing poly-unsaturated fatty acids.