The paper reports the biosynthesis of the main alkylpyridine alkaloids, haminol-1 (1) and -2 (2), in the Mediterranean mollusc Haminoea orbignyana. Experiments were carried out by in vivo incorporation of [1,2-13C2 acetate]. Data give full account for a polyketide origin of haminols in the Mediterranean molluscs, showing the biosynthesis of these 3-alkylpyridine alkaloids by elongation with acetate of a starter unit of nicotinic acid.
Polyketide origin of 3-alkylpyridines in the marine mollusc Haminoea orbignyana / Cutignano, A.; Cimino, G.; Giordano, A.; D’Ippolito, G.; Fontana, A. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 45:(2004), pp. 2627-2629. [10.1016/j.tetlet.2004.01.138]
Polyketide origin of 3-alkylpyridines in the marine mollusc Haminoea orbignyana
Fontana A
2004
Abstract
The paper reports the biosynthesis of the main alkylpyridine alkaloids, haminol-1 (1) and -2 (2), in the Mediterranean mollusc Haminoea orbignyana. Experiments were carried out by in vivo incorporation of [1,2-13C2 acetate]. Data give full account for a polyketide origin of haminols in the Mediterranean molluscs, showing the biosynthesis of these 3-alkylpyridine alkaloids by elongation with acetate of a starter unit of nicotinic acid.| File | Dimensione | Formato | |
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