Synthesis of a-6-sulfoquinovosyl-1,2-O-diacylglycerols is achieved by a versatile chemo-enzymatic stereoselective procedure that involves the use of a-D-glucosidase activity from the Mediterranean mollusc Aplysia fasciata. The synthetic procedure is designed to obtain a wide diversity of regio- and stereo-isomers of these compounds that have gained great interest as antineoplastic agents and potent inhibitors of DNA polymerases.
Chemoenzymatic preparation of α-6-sulfoquinovosyl-1,2-O-diacylglycerols / Manzo, E.; Tramice, A.; Pagano, D.; Trincone, A.; Fontana, A. - In: TETRAHEDRON. - ISSN 0040-4020. - 68:49(2012), pp. 10169-10175. [dx.doi.org/10.1016/j.tet.2012.09.100]
Chemoenzymatic preparation of α-6-sulfoquinovosyl-1,2-O-diacylglycerols
Fontana A
2012
Abstract
Synthesis of a-6-sulfoquinovosyl-1,2-O-diacylglycerols is achieved by a versatile chemo-enzymatic stereoselective procedure that involves the use of a-D-glucosidase activity from the Mediterranean mollusc Aplysia fasciata. The synthetic procedure is designed to obtain a wide diversity of regio- and stereo-isomers of these compounds that have gained great interest as antineoplastic agents and potent inhibitors of DNA polymerases.| File | Dimensione | Formato | |
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