Four new sesterterpenoids, ansellone B (4), phorbadione (5), secoepoxyansellone A (6), and alotaketal C (7), have been isolated from specimens of the sponge Phorbas sp. collected in British Columbia, Ansellone B (4) has an unprecedented heterocyclic skeleton featuring an oxocane ring, and secoepoxyansellone A (6) is the first example of the degraded "secoansellane" sesterterpenoid carbon skeleton. Alotaketal C (7) is an activator of cAMP signaling in HEK cells.
Sesterterpenoids Isolated from a Northeastern Pacific Phorbas sp / Daoust, Julie; Chen, Min; Wang, Meng; Williams David, E.; Chavez Miguel Angel, Garcia; Wang Yan, Alexander; Merchant Catherine, E.; Fontana, A; Kieffer Timothy, J.; Andersen Raymond, J.. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - 78:17(2013), pp. 8267-8273. [10.1021/jo4014589]
Sesterterpenoids Isolated from a Northeastern Pacific Phorbas sp
Fontana A;
2013
Abstract
Four new sesterterpenoids, ansellone B (4), phorbadione (5), secoepoxyansellone A (6), and alotaketal C (7), have been isolated from specimens of the sponge Phorbas sp. collected in British Columbia, Ansellone B (4) has an unprecedented heterocyclic skeleton featuring an oxocane ring, and secoepoxyansellone A (6) is the first example of the degraded "secoansellane" sesterterpenoid carbon skeleton. Alotaketal C (7) is an activator of cAMP signaling in HEK cells.| File | Dimensione | Formato | |
|---|---|---|---|
|
2013 JOC_Sesterterpenoids from Phorbas.pdf
non disponibili
Dimensione
1.07 MB
Formato
Adobe PDF
|
1.07 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
