Background: Vitamin D exerts multiple pleiotropic effects beyond its role in calcium-phosphate metabolism. Growing evidence suggests an association between hypovitaminosis D and sleep disorders, thus increasing the interest in the role of this vitamin in the regulatory mechanisms of the sleep-wake cycle. Objective: The study aimed to explore and summarize the current knowledge about the role of vitamin D in sleep regulation and the impact of vitamin D deficiency on sleep disorders. Methods: The main regulatory mechanisms of vitamin D on sleep are explained in this study. The literature was scanned to identify clinical trials and correlation studies showing an association between vitamin D deficiency and sleep disorders. Results: Vitamin D receptors and the enzymes that control their activation and degradation are expressed in several areas of the brain involved in sleep regulation. Vitamin D is also involved in the pathways of production of Melatonin, the hormone involved in the regulation of human circadian rhythms and sleep. Furthermore, vitamin D can affect sleep indirectly through non-specific pain disorders, correlated with alterations in sleep quality, such as restless legs syndrome and obstructive sleep apnea syndrome. Conclusions: Vitamin D has both a direct and an indirect role in the regulation of sleep. Although vitamin D deficiency has been associated to sleep disorders, there is still scant evidence to concretely support the role of vitamin D supplementation in the prevention or treatment of sleep disturbances; indeed, more intervention studies are needed to better clarify these aspects.

Vitamin D and sleep regulation: Is there a role for vitamin D? / Romano, F.; Muscogiuri, G.; Di Benedetto, E.; Zhukouskaya, V. V.; Barrea, L.; Savastano, S.; Colao, A.; Di Somma, C.. - In: CURRENT PHARMACEUTICAL DESIGN. - ISSN 1381-6128. - 26:21(2020), pp. 2492-2496. [10.2174/1381612826666200310145935]

Vitamin D and sleep regulation: Is there a role for vitamin D?

Romano F.
;
Muscogiuri G.;Di Benedetto E.;Barrea L.;Savastano S.;Colao A.;Di Somma C.
2020

Abstract

Background: Vitamin D exerts multiple pleiotropic effects beyond its role in calcium-phosphate metabolism. Growing evidence suggests an association between hypovitaminosis D and sleep disorders, thus increasing the interest in the role of this vitamin in the regulatory mechanisms of the sleep-wake cycle. Objective: The study aimed to explore and summarize the current knowledge about the role of vitamin D in sleep regulation and the impact of vitamin D deficiency on sleep disorders. Methods: The main regulatory mechanisms of vitamin D on sleep are explained in this study. The literature was scanned to identify clinical trials and correlation studies showing an association between vitamin D deficiency and sleep disorders. Results: Vitamin D receptors and the enzymes that control their activation and degradation are expressed in several areas of the brain involved in sleep regulation. Vitamin D is also involved in the pathways of production of Melatonin, the hormone involved in the regulation of human circadian rhythms and sleep. Furthermore, vitamin D can affect sleep indirectly through non-specific pain disorders, correlated with alterations in sleep quality, such as restless legs syndrome and obstructive sleep apnea syndrome. Conclusions: Vitamin D has both a direct and an indirect role in the regulation of sleep. Although vitamin D deficiency has been associated to sleep disorders, there is still scant evidence to concretely support the role of vitamin D supplementation in the prevention or treatment of sleep disturbances; indeed, more intervention studies are needed to better clarify these aspects.
2020
Vitamin D and sleep regulation: Is there a role for vitamin D? / Romano, F.; Muscogiuri, G.; Di Benedetto, E.; Zhukouskaya, V. V.; Barrea, L.; Savastano, S.; Colao, A.; Di Somma, C.. - In: CURRENT PHARMACEUTICAL DESIGN. - ISSN 1381-6128. - 26:21(2020), pp. 2492-2496. [10.2174/1381612826666200310145935]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/881058
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