A phytochemical investigation of the aerial parts of Euphorbia cactus Ehrenb. ex Boiss. revealed a new megastigmane, euphocactoside (5), along with eleven known metabolites. Euphocactoside (5) is the 3-O-glucoside derivative of a polyhydroxylated megastigmane showing unprecedented structural features. The structure of euphocactoside, including stereochemical details, was elucidated by extensive spectroscopic analysis based on 1D and 2D nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HR-ESIMS). The isolated compounds were evaluated for their cytotoxic activity against three different human cancer cell lines, namely, A549 (lung), LoVo (colon), and MCF-7 (breast), using MTT assay, and moderate to marginal activities were observed for compounds 1–3, 8 and 9 against all three cell lines.
Euphocactoside, a New Megastigmane Glycoside from Euphorbia cactus Growing in Saudi Arabia / Aati, H. Y.; Perveen, S.; Al-Qahtani, J.; Peng, J.; Al-Taweel, A.; Alqahtani, A. S.; Elgamal, A.; Chianese, G.; Nasr, F. A.; Taglialatela-Scafati, O.; Parvez, M. K.. - In: PLANTS. - ISSN 2223-7747. - 11:6(2022), p. 811. [10.3390/plants11060811]
Euphocactoside, a New Megastigmane Glycoside from Euphorbia cactus Growing in Saudi Arabia
Chianese G.Penultimo
Supervision
;Taglialatela-Scafati O.Membro del Collaboration Group
;
2022
Abstract
A phytochemical investigation of the aerial parts of Euphorbia cactus Ehrenb. ex Boiss. revealed a new megastigmane, euphocactoside (5), along with eleven known metabolites. Euphocactoside (5) is the 3-O-glucoside derivative of a polyhydroxylated megastigmane showing unprecedented structural features. The structure of euphocactoside, including stereochemical details, was elucidated by extensive spectroscopic analysis based on 1D and 2D nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HR-ESIMS). The isolated compounds were evaluated for their cytotoxic activity against three different human cancer cell lines, namely, A549 (lung), LoVo (colon), and MCF-7 (breast), using MTT assay, and moderate to marginal activities were observed for compounds 1–3, 8 and 9 against all three cell lines.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
