A collective total synthesis of eight diastereoisomers associated with NMR analysis leads to a full stereochemistry assignment of the structurally unique nucleoside antibiotic A-94964, which features an octuronic acid uridine core decorated with an α-D-mannopyranosyl residue and an α-D-N-acylglucosaminopyranosyl residue via a phosphodiester bridge.
Total Synthesis and Stereochemistry Assignment of Nucleoside Antibiotic A-94964 / Shao, X.; Zheng, C.; Xu, P.; Shiraishi, T.; Kuzuyama, T.; Molinaro, A.; Silipo, A.; Yu, B.. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 61:14(2022), pp. 1-7. [10.1002/anie.202200818]
Total Synthesis and Stereochemistry Assignment of Nucleoside Antibiotic A-94964
Molinaro A.;Silipo A.
;
2022
Abstract
A collective total synthesis of eight diastereoisomers associated with NMR analysis leads to a full stereochemistry assignment of the structurally unique nucleoside antibiotic A-94964, which features an octuronic acid uridine core decorated with an α-D-mannopyranosyl residue and an α-D-N-acylglucosaminopyranosyl residue via a phosphodiester bridge.File in questo prodotto:
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