Cellular compartments constituting the tumor microenvironment including immune cells, fibroblasts, endothelial cells, and mesenchymal stromal/stem cells communicate with malignant cells to orchestrate a series of signals that contribute to the evolution of the tumor microenvironment. In this study, we will focus on the interplay in tumor microenvironment between macrophages and mesenchymal stem cells and macrophages and fibroblasts. In particular, cell–cell interaction and mediators secreted by these cells will be examined to explain pro/anti-tumor phenotypes induced in macrophages. Nonetheless, in the context of virotherapy, the response of macrophages as a consequence of treatment with oncolytic viruses will be analyzed regarding their polarization status and their pro/anti-tumor response.

Cross talk of macrophages with tumor microenvironment cells and modulation of macrophages in cancer by virotherapy / Di Somma, S.; Napolitano, F.; Portella, G.; Malfitano, A. M.. - In: BIOMEDICINES. - ISSN 2227-9059. - 9:10(2021), p. 1309. [10.3390/biomedicines9101309]

Cross talk of macrophages with tumor microenvironment cells and modulation of macrophages in cancer by virotherapy

Di Somma S.;Napolitano F.;Portella G.;Malfitano A. M.
2021

Abstract

Cellular compartments constituting the tumor microenvironment including immune cells, fibroblasts, endothelial cells, and mesenchymal stromal/stem cells communicate with malignant cells to orchestrate a series of signals that contribute to the evolution of the tumor microenvironment. In this study, we will focus on the interplay in tumor microenvironment between macrophages and mesenchymal stem cells and macrophages and fibroblasts. In particular, cell–cell interaction and mediators secreted by these cells will be examined to explain pro/anti-tumor phenotypes induced in macrophages. Nonetheless, in the context of virotherapy, the response of macrophages as a consequence of treatment with oncolytic viruses will be analyzed regarding their polarization status and their pro/anti-tumor response.
2021
Cross talk of macrophages with tumor microenvironment cells and modulation of macrophages in cancer by virotherapy / Di Somma, S.; Napolitano, F.; Portella, G.; Malfitano, A. M.. - In: BIOMEDICINES. - ISSN 2227-9059. - 9:10(2021), p. 1309. [10.3390/biomedicines9101309]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/879771
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