Background and aim: The URRAH (URic acid Right for heArt Health) Study has identified cut-off values of serum uric acid (SUA) predictive of total mortality at 4.7 mg/dl, and cardiovascular (CV) mortality at 5.6 mg/dl. Our aim was to validate these SUA thresholds in people with diabetes. Methods and results: The URRAH subpopulation of people with diabetes was studied. All-cause and CV deaths were evaluated at the end of follow-up. A total of 2570 diabetic subjects were studied. During a median follow-up of 107 months, 744 deaths occurred. In the multivariate Cox regression analyses adjusted for several confounders, subjects with SUA ≥5.6 mg/dl had higher risk of total (HR: 1.23, 95%CI: 1.04-1.47) and CV mortality (HR:1.31, 95%CI:1.03-1.66), than those with SUA <5.6 mg/dl. Increased all-cause mortality risk was shown in participants with SUA ≥4.7 mg/dl vs SUA below 4.7 mg/dl, but not statistically significant after adjustment for all confounders. Conclusions: SUA thresholds previously proposed by the URRAH study group are predictive of total and CV mortality also in people with diabetes. The threshold of 5.6 mg/dl can predict both total and CV mortality, and so is candidate to be a clinical cut-off for the definition of hyperuricemia in patients with diabetes.

Serum uric acid levels threshold for mortality in diabetic individuals: The URic acid Right for heArt Health (URRAH) project / Masulli, Maria; D'Elia, Lanfranco; Angeli, Fabio; Barbagallo, Carlo M; Bilancio, Giancarlo; Bombelli, Michele; Bruno, Berardino; Casiglia, Edoardo; Cianci, Rosario; Cicero, Arrigo F G; Cirillo, Massimo; Cirillo, Pietro; Dell'Oro, Raffaella; Desideri, Giovambattista; Ferri, Claudio; Gesualdo, Loreto; Giannattasio, Cristina; Grassi, Guido; Iaccarino, Guido; Lippa, Luciano; Mallamaci, Francesca; Maloberti, Alessandro; Masi, Stefano; Mazza, Alberto; Mengozzi, Alessandro; Muiesan, Maria Lorenza; Nazzaro, Pietro; Palatini, Paolo; Parati, Gianfranco; Pontremoli, Roberto; Quarti-Trevano, Fosca; Rattazzi, Marcello; Reboldi, Gianpaolo; Rivasi, Giulia; Salvetti, Massimo; Tikhonoff, Valerie; Tocci, Giuliano; Ungar, Andrea; Verdecchia, Paolo; Viazzi, Francesca; Virdis, Agostino; Volpe, Massimo; Borghi, Claudio; Galletti, Ferruccio. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - (2022). [10.1016/j.numecd.2022.01.028]

Serum uric acid levels threshold for mortality in diabetic individuals: The URic acid Right for heArt Health (URRAH) project

Masulli, Maria;D'Elia, Lanfranco;Cirillo, Massimo;Ferri, Claudio;Giannattasio, Cristina;Iaccarino, Guido;Muiesan, Maria Lorenza;Galletti, Ferruccio
2022

Abstract

Background and aim: The URRAH (URic acid Right for heArt Health) Study has identified cut-off values of serum uric acid (SUA) predictive of total mortality at 4.7 mg/dl, and cardiovascular (CV) mortality at 5.6 mg/dl. Our aim was to validate these SUA thresholds in people with diabetes. Methods and results: The URRAH subpopulation of people with diabetes was studied. All-cause and CV deaths were evaluated at the end of follow-up. A total of 2570 diabetic subjects were studied. During a median follow-up of 107 months, 744 deaths occurred. In the multivariate Cox regression analyses adjusted for several confounders, subjects with SUA ≥5.6 mg/dl had higher risk of total (HR: 1.23, 95%CI: 1.04-1.47) and CV mortality (HR:1.31, 95%CI:1.03-1.66), than those with SUA <5.6 mg/dl. Increased all-cause mortality risk was shown in participants with SUA ≥4.7 mg/dl vs SUA below 4.7 mg/dl, but not statistically significant after adjustment for all confounders. Conclusions: SUA thresholds previously proposed by the URRAH study group are predictive of total and CV mortality also in people with diabetes. The threshold of 5.6 mg/dl can predict both total and CV mortality, and so is candidate to be a clinical cut-off for the definition of hyperuricemia in patients with diabetes.
2022
Serum uric acid levels threshold for mortality in diabetic individuals: The URic acid Right for heArt Health (URRAH) project / Masulli, Maria; D'Elia, Lanfranco; Angeli, Fabio; Barbagallo, Carlo M; Bilancio, Giancarlo; Bombelli, Michele; Bruno, Berardino; Casiglia, Edoardo; Cianci, Rosario; Cicero, Arrigo F G; Cirillo, Massimo; Cirillo, Pietro; Dell'Oro, Raffaella; Desideri, Giovambattista; Ferri, Claudio; Gesualdo, Loreto; Giannattasio, Cristina; Grassi, Guido; Iaccarino, Guido; Lippa, Luciano; Mallamaci, Francesca; Maloberti, Alessandro; Masi, Stefano; Mazza, Alberto; Mengozzi, Alessandro; Muiesan, Maria Lorenza; Nazzaro, Pietro; Palatini, Paolo; Parati, Gianfranco; Pontremoli, Roberto; Quarti-Trevano, Fosca; Rattazzi, Marcello; Reboldi, Gianpaolo; Rivasi, Giulia; Salvetti, Massimo; Tikhonoff, Valerie; Tocci, Giuliano; Ungar, Andrea; Verdecchia, Paolo; Viazzi, Francesca; Virdis, Agostino; Volpe, Massimo; Borghi, Claudio; Galletti, Ferruccio. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - (2022). [10.1016/j.numecd.2022.01.028]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/878217
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