In this work CeO2 nanoparticles (CeO2-NPs) were synthesized through the thermal de-composition of Ce(NO3)3·6H2O, using as capping agents either octylamine or oleylamine, to evaluate the effect of alkyl chain length, an issue at 150 °C, in the case of octylamine and at 150 and 250 °C, in the case of oleylamine, to evaluate the effect of the temperature on NPs properties. All the nanoparticles were extensively characterized by a multidisciplinary approach, such as wide-angle X-ray diffraction, transmission electron microscopy, dynamic light scattering, UV-Vis, fluorescence, Raman and FTIR spectroscopies. The analysis of the experimental data shows that the capping agent nature and the synthesis temperature affect nanoparticle properties including size, morphology, aggregation and Ce3+/Ce4+ ratio. Such issues have not been discussed yet, at the best of our knowledge, in the literature. Notably, CeO2-NPs synthesized in the presence of oleylamine at 250 °C showed no tendency to aggregation and we made them water-soluble through a further coating with sodium oleate. The obtained nanoparticles show a less tendency to clustering forming stable aggregates (ranging between 14 and 22 nm) of few NPs. These were tested for biocompatibility and ROS inhibiting activity, demonstrating a remarkable antioxidant activity, against oxidative stress.

Towards the development of antioxidant cerium oxide nanoparticles for biomedical applications: Controlling the properties by tuning synthesis conditions / Gallucci, N.; Vitiello, G.; Di Girolamo, R.; Imbimbo, P.; Monti, D. M.; Tarallo, O.; Vergara, A.; Krauss, I. R.; Paduano, L.. - In: NANOMATERIALS. - ISSN 2079-4991. - 11:2(2021), pp. 1-18. [10.3390/nano11020542]

Towards the development of antioxidant cerium oxide nanoparticles for biomedical applications: Controlling the properties by tuning synthesis conditions

Gallucci N.;Vitiello G.;Di Girolamo R.;Imbimbo P.;Monti D. M.;Tarallo O.;Vergara A.;Krauss I. R.;Paduano L.
2021

Abstract

In this work CeO2 nanoparticles (CeO2-NPs) were synthesized through the thermal de-composition of Ce(NO3)3·6H2O, using as capping agents either octylamine or oleylamine, to evaluate the effect of alkyl chain length, an issue at 150 °C, in the case of octylamine and at 150 and 250 °C, in the case of oleylamine, to evaluate the effect of the temperature on NPs properties. All the nanoparticles were extensively characterized by a multidisciplinary approach, such as wide-angle X-ray diffraction, transmission electron microscopy, dynamic light scattering, UV-Vis, fluorescence, Raman and FTIR spectroscopies. The analysis of the experimental data shows that the capping agent nature and the synthesis temperature affect nanoparticle properties including size, morphology, aggregation and Ce3+/Ce4+ ratio. Such issues have not been discussed yet, at the best of our knowledge, in the literature. Notably, CeO2-NPs synthesized in the presence of oleylamine at 250 °C showed no tendency to aggregation and we made them water-soluble through a further coating with sodium oleate. The obtained nanoparticles show a less tendency to clustering forming stable aggregates (ranging between 14 and 22 nm) of few NPs. These were tested for biocompatibility and ROS inhibiting activity, demonstrating a remarkable antioxidant activity, against oxidative stress.
2021
Towards the development of antioxidant cerium oxide nanoparticles for biomedical applications: Controlling the properties by tuning synthesis conditions / Gallucci, N.; Vitiello, G.; Di Girolamo, R.; Imbimbo, P.; Monti, D. M.; Tarallo, O.; Vergara, A.; Krauss, I. R.; Paduano, L.. - In: NANOMATERIALS. - ISSN 2079-4991. - 11:2(2021), pp. 1-18. [10.3390/nano11020542]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/876871
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