In this paper, different nanostructured semiconductors with advanced properties are explored for the realization of both optical and electrical biosensors for DNA detection. A hybrid sensor constituted by graphene oxide (GO) covalently grafted on a porous silicon (PSi) matrix is realized. A peptide nucleic acid (PNA) probe, able to recognize its complementary DNA (c-DNA) sequence, is immobilized on the surface of PSi/GO device for label-free optical sensing. Electrical sensing of DNA is also demonstrated using a Zinc Oxide Nanowires (ZnONWs) sensor functionalized with PNA probe; the I–V characteristic of the device depends on the c-DNA concentration under analysis.

Hybrid Organic/Inorganic Nanomaterials for Biochemical Sensing

Rea, Ilaria
;
Dardano, Principia;Moretta, Rosalba;Schiattarella, Chiara;Terracciano, Monica;Crisci, Teresa;Chianese, Giovanna;Tramontano, Chiara;Borbone, Nicola;
2021

Abstract

In this paper, different nanostructured semiconductors with advanced properties are explored for the realization of both optical and electrical biosensors for DNA detection. A hybrid sensor constituted by graphene oxide (GO) covalently grafted on a porous silicon (PSi) matrix is realized. A peptide nucleic acid (PNA) probe, able to recognize its complementary DNA (c-DNA) sequence, is immobilized on the surface of PSi/GO device for label-free optical sensing. Electrical sensing of DNA is also demonstrated using a Zinc Oxide Nanowires (ZnONWs) sensor functionalized with PNA probe; the I–V characteristic of the device depends on the c-DNA concentration under analysis.
978-3-030-69550-7
978-3-030-69551-4
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/872604
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