The role of folate-dependent one carbon (1C) metabolism in CD4+ T cell polarization is incompletely understood. In this issue of Immunity, Sugiura et al. (2021) provide evidence that blocking the 1C metabolic enzyme MTHFD2 may curb pro-inflammatory CD4+ T cells, while redirecting them toward a regulatory T cell phenotype.
The folate way to T cell fate / de Candia, P.; Matarese, G.. - In: IMMUNITY. - ISSN 1097-4180. - 55:1(2022), pp. 1-3. [10.1016/j.immuni.2021.12.009]
The folate way to T cell fate
de Candia P.
Primo
;Matarese G.
Ultimo
2022
Abstract
The role of folate-dependent one carbon (1C) metabolism in CD4+ T cell polarization is incompletely understood. In this issue of Immunity, Sugiura et al. (2021) provide evidence that blocking the 1C metabolic enzyme MTHFD2 may curb pro-inflammatory CD4+ T cells, while redirecting them toward a regulatory T cell phenotype.File in questo prodotto:
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