Analysis of UV-visible spectra, performed on commercial riboflavin-based eye drops, showed that absorbance is a saturating function of vitamin concentration. This implies a threshold concentration, Ct, such that for riboflavin concentration > Ct the absorbance remains constant and the effectiveness of the eye drops is independent of the dose used. These experimental results were combined with a diffusion-reaction model to elucidate the mechanism of action within the cornea. The model predicts that the eye drops have a low effectiveness on UVB and UVC, while they have a good performance for UVA. Indeed, at the center of the cornea the transmittance is significantly reduced and after 1 h it is reduced by about 70% compared to a cornea devoid of eye drops.
Reaction-diffusion model as framework for understanding the role of riboflavin in "eye defence" formulations / Di Nezza, F.; Caruso, C.; Costagliola, C.; Ambrosone, L.. - In: RSC ADVANCES. - ISSN 2046-2069. - 10:25(2020), pp. 14965-14971. [10.1039/d0ra00417k]
Reaction-diffusion model as framework for understanding the role of riboflavin in "eye defence" formulations
Costagliola C.;
2020
Abstract
Analysis of UV-visible spectra, performed on commercial riboflavin-based eye drops, showed that absorbance is a saturating function of vitamin concentration. This implies a threshold concentration, Ct, such that for riboflavin concentration > Ct the absorbance remains constant and the effectiveness of the eye drops is independent of the dose used. These experimental results were combined with a diffusion-reaction model to elucidate the mechanism of action within the cornea. The model predicts that the eye drops have a low effectiveness on UVB and UVC, while they have a good performance for UVA. Indeed, at the center of the cornea the transmittance is significantly reduced and after 1 h it is reduced by about 70% compared to a cornea devoid of eye drops.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
