: Lipopolysaccharide (LPS) is a crucial constituent of the outer membrane of most Gram-negative bacteria, playing a fundamental role in the protection of bacteria from environmental stress factors, in drug resistance, in pathogenesis, and in symbiosis. During the last decades, LPS has been thoroughly dissected, and massive information on this fascinating biomolecule is now available. In this Review, we will give the reader a third millennium update of the current knowledge of LPS with key information on the inherent peculiar carbohydrate chemistry due to often puzzling sugar residues that are uniquely found on it. Then, we will drive the reader through the complex and multifarious immunological outcomes that any given LPS can raise, which is strictly dependent on its chemical structure. Further, we will argue about issues that still remain unresolved and that would represent the immediate future of LPS research. It is critical to address these points to complete our notions on LPS chemistry, functions, and roles, in turn leading to innovative ways to manipulate the processes involving such a still controversial and intriguing biomolecule.

A Journey from Structure to Function of Bacterial Lipopolysaccharides / Di Lorenzo, Flaviana; Duda, Katarzyna A; Lanzetta, Rosa; Silipo, Alba; De Castro, Cristina; Molinaro, Antonio. - In: CHEMICAL REVIEWS. - ISSN 1520-6890. - 122:(2022), pp. 15767-15821. [10.1021/acs.chemrev.0c01321]

A Journey from Structure to Function of Bacterial Lipopolysaccharides

Di Lorenzo, Flaviana;Lanzetta, Rosa;Silipo, Alba;De Castro, Cristina;Molinaro, Antonio
2022

Abstract

: Lipopolysaccharide (LPS) is a crucial constituent of the outer membrane of most Gram-negative bacteria, playing a fundamental role in the protection of bacteria from environmental stress factors, in drug resistance, in pathogenesis, and in symbiosis. During the last decades, LPS has been thoroughly dissected, and massive information on this fascinating biomolecule is now available. In this Review, we will give the reader a third millennium update of the current knowledge of LPS with key information on the inherent peculiar carbohydrate chemistry due to often puzzling sugar residues that are uniquely found on it. Then, we will drive the reader through the complex and multifarious immunological outcomes that any given LPS can raise, which is strictly dependent on its chemical structure. Further, we will argue about issues that still remain unresolved and that would represent the immediate future of LPS research. It is critical to address these points to complete our notions on LPS chemistry, functions, and roles, in turn leading to innovative ways to manipulate the processes involving such a still controversial and intriguing biomolecule.
2022
A Journey from Structure to Function of Bacterial Lipopolysaccharides / Di Lorenzo, Flaviana; Duda, Katarzyna A; Lanzetta, Rosa; Silipo, Alba; De Castro, Cristina; Molinaro, Antonio. - In: CHEMICAL REVIEWS. - ISSN 1520-6890. - 122:(2022), pp. 15767-15821. [10.1021/acs.chemrev.0c01321]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/865769
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