The Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has rapidly spread to become a global pandemic, putting a strain on health care systems. SARS-CoV-2 infection may be associated with mild symptoms or, in severe cases, lead patients to the intensive care unit (ICU) or death. The critically ill patients suffer from acute respiratory distress syndrome (ARDS), sepsis, thrombotic complications and multiple organ failure. For optimization of hospital resources, several molecular markers and algorithms have been evaluated in order to stratify COVID-19 patients, based on the risk of developing a mild, moderate, or severe disease. Here, we propose the soluble urokinase receptor (suPAR) as a serum biomarker of clinical severity and outcome in patients who are hospitalized with COVID-19. In patients with mild disease course, suPAR levels were increased as compared to healthy controls, but they were dramatically higher in severely ill patients. Since early identification of disease progression may facilitate the individual management of COVID-19 symptomatic patients and the time of admission to the ICU, we suggest paying more clinical attention on patients with high suPAR levels.

Soluble urokinase receptor as a promising marker for early prediction of outcome in covid-19 hospitalized patients / Napolitano, F.; Di Spigna, G.; Vargas, M.; Iacovazzo, C.; Pinchera, B.; Cernia, D. S.; Ricciardone, M.; Covelli, B.; Servillo, G.; Gentile, I.; Postiglione, L.; Montuori, N.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 10:21(2021), pp. 4914-4927. [10.3390/jcm10214914]

Soluble urokinase receptor as a promising marker for early prediction of outcome in covid-19 hospitalized patients

Napolitano F.;Di Spigna G.;Vargas M.;Iacovazzo C.;Pinchera B.;Ricciardone M.;Covelli B.;Servillo G.;Gentile I.;Postiglione L.;Montuori N.
2021

Abstract

The Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has rapidly spread to become a global pandemic, putting a strain on health care systems. SARS-CoV-2 infection may be associated with mild symptoms or, in severe cases, lead patients to the intensive care unit (ICU) or death. The critically ill patients suffer from acute respiratory distress syndrome (ARDS), sepsis, thrombotic complications and multiple organ failure. For optimization of hospital resources, several molecular markers and algorithms have been evaluated in order to stratify COVID-19 patients, based on the risk of developing a mild, moderate, or severe disease. Here, we propose the soluble urokinase receptor (suPAR) as a serum biomarker of clinical severity and outcome in patients who are hospitalized with COVID-19. In patients with mild disease course, suPAR levels were increased as compared to healthy controls, but they were dramatically higher in severely ill patients. Since early identification of disease progression may facilitate the individual management of COVID-19 symptomatic patients and the time of admission to the ICU, we suggest paying more clinical attention on patients with high suPAR levels.
2021
Soluble urokinase receptor as a promising marker for early prediction of outcome in covid-19 hospitalized patients / Napolitano, F.; Di Spigna, G.; Vargas, M.; Iacovazzo, C.; Pinchera, B.; Cernia, D. S.; Ricciardone, M.; Covelli, B.; Servillo, G.; Gentile, I.; Postiglione, L.; Montuori, N.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 10:21(2021), pp. 4914-4927. [10.3390/jcm10214914]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/863692
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 14
social impact