Purpose: We assessed the impact of COVID-19 infection on cardiovascular events in patients with suspected or known coronary artery disease (CAD) referred to stress single-photon emission computed tomography myocardial perfusion imaging (MPS). Methods: A total of 960 consecutive patients with suspected or known CAD were submitted by referring physicians to stress MPS for assessment of myocardial ischemia between January 2018 and June 2019. All patients underwent stress-optional rest MPS. Perfusion defects were quantitated as % of LV myocardium and expressed as total perfusion defect (TPD), representing the defect extent and severity. A TPD ≥ 5% was considered abnormal. Results: During a mean follow-up of 27 months (range 4-38) 31 events occurred. Moreover, 55 (6%) patients had a COVID-19 infection. The median time from index MPS to COVID-19 infection was 16 months (range 6-24). At Cox multivariable analysis, abnormal MPS and COVID-19 infection resulted as independent predictors of events. There were no significant differences in annualized event rate in COVID-19 patients with or without abnormal MPS (p = 0.56). Differently, in patients without COVID-19, the presence of abnormal MPS was associated with higher event rate (p < .001). Patients with infection compared to those without had a higher event rate in the presence of both normal and abnormal TPD. Conclusion: In patients with suspected or known CAD, the presence of COVID-19 infection during a short-term follow-up was associated with a higher rate of cardiovascular events.

Impact of COVID-19 infection on short-term outcome in patients referred to stress myocardial perfusion imaging / Assante, Roberta; D’Antonio, Adriana; Mannarino, Teresa; Gaudieri, Valeria; Zampella, Emilia; Mainolfi, Ciro Gabriele; Cantoni, Valeria; Green, Roberta; Caiazzo, Elisa; Nappi, Carmela; Criscuolo, Emanuele; Bologna, Roberto; Zumbo, Giulia; Petretta, Mario; Cuocolo, Alberto; Acampa, Wanda. - In: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. - ISSN 1619-7070. - 49:(2022), pp. 1544-1552. [10.1007/s00259-021-05619-2]

Impact of COVID-19 infection on short-term outcome in patients referred to stress myocardial perfusion imaging

Assante, Roberta;D’Antonio, Adriana;Mannarino, Teresa;Gaudieri, Valeria
;
Zampella, Emilia;Mainolfi, Ciro Gabriele;Cantoni, Valeria;Green, Roberta;Caiazzo, Elisa;Nappi, Carmela;Criscuolo, Emanuele;Bologna, Roberto;Zumbo, Giulia;Petretta, Mario;Cuocolo, Alberto;Acampa, Wanda
2022

Abstract

Purpose: We assessed the impact of COVID-19 infection on cardiovascular events in patients with suspected or known coronary artery disease (CAD) referred to stress single-photon emission computed tomography myocardial perfusion imaging (MPS). Methods: A total of 960 consecutive patients with suspected or known CAD were submitted by referring physicians to stress MPS for assessment of myocardial ischemia between January 2018 and June 2019. All patients underwent stress-optional rest MPS. Perfusion defects were quantitated as % of LV myocardium and expressed as total perfusion defect (TPD), representing the defect extent and severity. A TPD ≥ 5% was considered abnormal. Results: During a mean follow-up of 27 months (range 4-38) 31 events occurred. Moreover, 55 (6%) patients had a COVID-19 infection. The median time from index MPS to COVID-19 infection was 16 months (range 6-24). At Cox multivariable analysis, abnormal MPS and COVID-19 infection resulted as independent predictors of events. There were no significant differences in annualized event rate in COVID-19 patients with or without abnormal MPS (p = 0.56). Differently, in patients without COVID-19, the presence of abnormal MPS was associated with higher event rate (p < .001). Patients with infection compared to those without had a higher event rate in the presence of both normal and abnormal TPD. Conclusion: In patients with suspected or known CAD, the presence of COVID-19 infection during a short-term follow-up was associated with a higher rate of cardiovascular events.
2022
Impact of COVID-19 infection on short-term outcome in patients referred to stress myocardial perfusion imaging / Assante, Roberta; D’Antonio, Adriana; Mannarino, Teresa; Gaudieri, Valeria; Zampella, Emilia; Mainolfi, Ciro Gabriele; Cantoni, Valeria; Green, Roberta; Caiazzo, Elisa; Nappi, Carmela; Criscuolo, Emanuele; Bologna, Roberto; Zumbo, Giulia; Petretta, Mario; Cuocolo, Alberto; Acampa, Wanda. - In: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. - ISSN 1619-7070. - 49:(2022), pp. 1544-1552. [10.1007/s00259-021-05619-2]
File in questo prodotto:
File Dimensione Formato  
Assante et al. Eur J Nucl Med Molec Imaging (2022).pdf

solo utenti autorizzati

Descrizione: Articolo su rivista
Tipologia: Versione Editoriale (PDF)
Licenza: Creative commons
Dimensione 827.21 kB
Formato Adobe PDF
827.21 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/862573
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 5
social impact