The COVID-19 pandemic stimulated the production of unconventional mRNA (messenger RNA) vaccines. Theoretically, any mRNA could be recognized by the molecular machinery of the endogenous L1 retroelements and so far could be integrated into the genome in the form of a new copy of DNA. In our opinion, further studies are needed to be able to understand both the real mutagenicity of mRNA vaccines and how to limit the effects of L1 on mRNA vaccine retro-integration.
mRNA vaccines: Why and how they should be modified / Feliciello, Isidoro; Procino, Alfredo. - In: JOURNAL OF BIOLOGICAL RESEARCH. - ISSN 2284-0230. - (2021). [10.4081/jbr.2021.10072]
mRNA vaccines: Why and how they should be modified
Feliciello, Isidoro
Primo
Conceptualization
;Procino, AlfredoSecondo
Membro del Collaboration Group
2021
Abstract
The COVID-19 pandemic stimulated the production of unconventional mRNA (messenger RNA) vaccines. Theoretically, any mRNA could be recognized by the molecular machinery of the endogenous L1 retroelements and so far could be integrated into the genome in the form of a new copy of DNA. In our opinion, further studies are needed to be able to understand both the real mutagenicity of mRNA vaccines and how to limit the effects of L1 on mRNA vaccine retro-integration.| File | Dimensione | Formato | |
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20021 mRNA vaccines_ Why and how they should be modified.pdf
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