Precision medicine is based on innovative administration methods of active principles. Drug delivery on tissue of interest allows improving the therapeutic index and reducing the side effects. Active targeting by means of drug-encapsulated micelles decorated with targeting bioactive moieties represents a new frontier. Between the bioactive moieties, peptides, for their versatility, easy synthesis and immunogenicity, can be selected to direct a drug toward a considerable number of molecular targets overexpressed on both cancer vasculature and cancer cells. Moreover, short peptide sequences can facilitate cellular intake. This review focuses on micelles achieved by self-assembling or mixing peptide-grafted surfactants or peptide-decorated amphiphilic copolymers. Nanovectors loaded with hydrophobic or hydrophilic cytotoxic drugs or with gene silence sequences and externally functionalized with natural or synthetic peptides are described based on their formulation and in vitro and in vivo behaviors.

Forward precision medicine: Micelles for active targeting driven by peptides / Prencipe, F.; Diaferia, C.; Rossi, F.; Ronga, L.; Tesauro, D.. - In: MOLECULES. - ISSN 1420-3049. - 26:13(2021), p. 4049. [10.3390/molecules26134049]

Forward precision medicine: Micelles for active targeting driven by peptides

Diaferia C.
Data Curation
;
Rossi F.
Writing – Original Draft Preparation
;
Ronga L.
Writing – Review & Editing
;
Tesauro D.
Writing – Original Draft Preparation
2021

Abstract

Precision medicine is based on innovative administration methods of active principles. Drug delivery on tissue of interest allows improving the therapeutic index and reducing the side effects. Active targeting by means of drug-encapsulated micelles decorated with targeting bioactive moieties represents a new frontier. Between the bioactive moieties, peptides, for their versatility, easy synthesis and immunogenicity, can be selected to direct a drug toward a considerable number of molecular targets overexpressed on both cancer vasculature and cancer cells. Moreover, short peptide sequences can facilitate cellular intake. This review focuses on micelles achieved by self-assembling or mixing peptide-grafted surfactants or peptide-decorated amphiphilic copolymers. Nanovectors loaded with hydrophobic or hydrophilic cytotoxic drugs or with gene silence sequences and externally functionalized with natural or synthetic peptides are described based on their formulation and in vitro and in vivo behaviors.
2021
Forward precision medicine: Micelles for active targeting driven by peptides / Prencipe, F.; Diaferia, C.; Rossi, F.; Ronga, L.; Tesauro, D.. - In: MOLECULES. - ISSN 1420-3049. - 26:13(2021), p. 4049. [10.3390/molecules26134049]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/855056
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