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The epilepsies affect around 65 million people worldwide and have a substantial missing heritability component. We report a genome-wide mega-analysis involving 15,212 individuals with epilepsy and 29,677 controls, which reveals 16 genome-wide significant loci, of which 11 are novel. Using various prioritization criteria, we pinpoint the 21 most likely epilepsy genes at these loci, with the majority in genetic generalized epilepsies. These genes have diverse biological functions, including coding for ion-channel subunits, transcription factors and a vitamin-B6 metabolism enzyme. Converging evidence shows that the common variants associated with epilepsy play a role in epigenetic regulation of gene expression in the brain. The results show an enrichment for monogenic epilepsy genes as well as known targets of antiepileptic drugs. Using SNP-based heritability analyses we disentangle both the unique and overlapping genetic basis to seven different epilepsy subtypes. Together, these findings provide leads for epilepsy therapies based on underlying pathophysiology.
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies / Abou-Khalil, Bassel; Auce, Pauls; Avbersek, Andreja; Bahlo, Melanie; J Balding, David; Bast, Thomas; Baum, Larry; J Becker, Albert; Becker, Felicitas; Berghuis, Bianca; F Berkovic, Samuel; E Boysen, Katja; P Bradfield, Jonathan; C Brody, Lawrence; J Buono, Russell; Campbell, Ellen; D Cascino, Gregory; B Catarino, Claudia; L Cavalleri, Gianpiero; S Cherny, Stacey; Chinthapalli, Krishna; J Coffey, Alison; Compston, Alastair; Coppola, Antonietta; Cossette, Patrick; J Craig, John; de Haan, Gerrit-Jan; De Jonghe, Peter; F de Kovel, Carolien G; Delanty, Norman; Depondt, Chantal; Devinsky, Orrin; J Dlugos, Dennis; P Doherty, Colin; E Elger, Christian; G Eriksson, Johan; N Ferraro, Thomas; Feucht, Martha; Francis, Ben; Franke, Andre; A French, Jacqueline; Freytag, Saskia; Gaus, Verena; B Geller, Eric; Gieger, Christian; Glauser, Tracy; Glynn, Simon; B Goldstein, David; Gui, Hongsheng; Guo, Youling; F Haas, Kevin; Hakonarson, Hakon; Hallmann, Kerstin; Haut, Sheryl; L Heinzen, Erin; Helbig, Ingo; Hengsbach, Christian; Hjalgrim, Helle; Iacomino, Michele; Ingason, Andrés; Jamnadas-Khoda, Jennifer; R Johnson, Michael; Kälviäinen, Reetta; Kantanen, Anne-Mari; Kasperavičiūte, Dalia; Kasteleijn-Nolst Trenite, Dorothee; E Kirsch, Heidi; C Knowlton, Robert; C Koeleman, Bobby P; Krause, Roland; Krenn, Martin; S Kunz, Wolfram; Kuzniecky, Ruben; Kwan, Patrick; Lal, Dennis; Lau, Yu-Lung; Lehesjoki, Anna-Elina; Lerche, Holger; Leu, Costin; Lieb, Wolfgang; Lindhout, Dick; D Lo, Warren; Lopes-Cendes, Iscia; H Lowenstein, Daniel; Malovini, Alberto; G Marson, Anthony; Mayer, Thomas; Mccormack, Mark; L Mills, James; Mirza, Nasir; Moerzinger, Martina; S Møller, Rikke; M Molloy, Anne; Muhle, Hiltrud; Newton, Mark; Ng, Ping-Wing; M Nöthen, Markus; Nürnberg, Peter; J O'Brien, Terence; L Oliver, Karen; Palotie, Aarno; Pangilinan, Faith; Peter, Sarah; Petrovski, Slavé; Poduri, Annapurna; Privitera, Michael; Radtke, Rodney; Rau, Sarah; S Reif, Philipp; M Reinthaler, Eva; Rosenow, Felix; W Sander, Josemir; Sander, Thomas; Scattergood, Theresa; C Schachter, Steven; J Schankin, Christoph; E Scheffer, Ingrid; Schmitz, Bettina; Schoch, Susanne; C Sham, Pak; J Shih, Jerry; J Sills, Graeme; M Sisodiya, Sanjay; Slattery, Lisa; Smith, Alexander; F Smith, David; C Smith, Michael; E Smith, Philip; M Sonsma, Anja C; Speed, Doug; R Sperling, Michael; J Steinhoff, Bernhard; Stephani, Ulrich; Stevelink, Remi; Strauch, Konstantin; Striano, Pasquale; Stroink, Hans; Surges, Rainer; Meng Tan, K; Lin Thio, Liu; Neil Thomas, G; Todaro, Marian; Tozzi, Rossana; S Vari, Maria; G Vining, Eileen P; Visscher, Frank; von Spiczak, Sarah; M Walley, Nicole; G Weber, Yvonne; Wei, Zhi; Weisenberg, Judith; D Whelan, Christopher; Widdess-Walsh, Peter; Wolff, Markus; Wolking, Stefan; Yang, Wanling; Zara, Federico; Zimprich, Fritz. - In: NATURE COMMUNICATIONS. - ISSN 2041-1723. - 9:1(2018), p. 5269. [10.1038/s41467-018-07524-z]
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies
Bassel Abou-Khalil;Pauls Auce;Andreja Avbersek;Melanie Bahlo;David J Balding;Thomas Bast;Larry Baum;Albert J Becker;Felicitas Becker;Bianca Berghuis;Samuel F Berkovic;Katja E Boysen;Jonathan P Bradfield;Lawrence C Brody;Russell J Buono;Ellen Campbell;Gregory D Cascino;Claudia B Catarino;Gianpiero L Cavalleri;Stacey S Cherny;Krishna Chinthapalli;Alison J Coffey;Alastair Compston;Antonietta Coppola;Patrick Cossette;John J Craig;Gerrit-Jan de Haan;Peter De Jonghe;Carolien G F de Kovel;Norman Delanty;Chantal Depondt;Orrin Devinsky;Dennis J Dlugos;Colin P Doherty;Christian E Elger;Johan G Eriksson;Thomas N Ferraro;Martha Feucht;Ben Francis;Andre Franke;Jacqueline A French;Saskia Freytag;Verena Gaus;Eric B Geller;Christian Gieger;Tracy Glauser;Simon Glynn;David B Goldstein;Hongsheng Gui;Youling Guo;Kevin F Haas;Hakon Hakonarson;Kerstin Hallmann;Sheryl Haut;Erin L Heinzen;Ingo Helbig;Christian Hengsbach;Helle Hjalgrim;Michele Iacomino;Andrés Ingason;Jennifer Jamnadas-Khoda;Michael R Johnson;Reetta Kälviäinen;Anne-Mari Kantanen;Dalia Kasperavičiūte;Dorothee Kasteleijn-Nolst Trenite;Heidi E Kirsch;Robert C Knowlton;Bobby P C Koeleman;Roland Krause;Martin Krenn;Wolfram S Kunz;Ruben Kuzniecky;Patrick Kwan;Dennis Lal;Yu-Lung Lau;Anna-Elina Lehesjoki;Holger Lerche;Costin Leu;Wolfgang Lieb;Dick Lindhout;Warren D Lo;Iscia Lopes-Cendes;Daniel H Lowenstein;Alberto Malovini;Anthony G Marson;Thomas Mayer;Mark McCormack;James L Mills;Nasir Mirza;Martina Moerzinger;Rikke S Møller;Anne M Molloy;Hiltrud Muhle;Mark Newton;Ping-Wing Ng;Markus M Nöthen;Peter Nürnberg;Terence J O'Brien;Karen L Oliver;Aarno Palotie;Faith Pangilinan;Sarah Peter;Slavé Petrovski;Annapurna Poduri;Michael Privitera;Rodney Radtke;Sarah Rau;Philipp S Reif;Eva M Reinthaler;Felix Rosenow;Josemir W Sander;Thomas Sander;Theresa Scattergood;Steven C Schachter;Christoph J Schankin;Ingrid E Scheffer;Bettina Schmitz;Susanne Schoch;Pak C Sham;Jerry J Shih;Graeme J Sills;Sanjay M Sisodiya;Lisa Slattery;Alexander Smith;David F Smith;Michael C Smith;Philip E Smith;Anja C M Sonsma;Doug Speed;Michael R Sperling;Bernhard J Steinhoff;Ulrich Stephani;Remi Stevelink;Konstantin Strauch;Pasquale Striano;Hans Stroink;Rainer Surges;K Meng Tan;Liu Lin Thio;G Neil Thomas;Marian Todaro;Rossana Tozzi;Maria S Vari;Eileen P G Vining;Frank Visscher;Sarah von Spiczak;Nicole M Walley;Yvonne G Weber;Zhi Wei;Judith Weisenberg;Christopher D Whelan;Peter Widdess-Walsh;Markus Wolff;Stefan Wolking;Wanling Yang;Federico Zara;Fritz Zimprich
2018
Abstract
The epilepsies affect around 65 million people worldwide and have a substantial missing heritability component. We report a genome-wide mega-analysis involving 15,212 individuals with epilepsy and 29,677 controls, which reveals 16 genome-wide significant loci, of which 11 are novel. Using various prioritization criteria, we pinpoint the 21 most likely epilepsy genes at these loci, with the majority in genetic generalized epilepsies. These genes have diverse biological functions, including coding for ion-channel subunits, transcription factors and a vitamin-B6 metabolism enzyme. Converging evidence shows that the common variants associated with epilepsy play a role in epigenetic regulation of gene expression in the brain. The results show an enrichment for monogenic epilepsy genes as well as known targets of antiepileptic drugs. Using SNP-based heritability analyses we disentangle both the unique and overlapping genetic basis to seven different epilepsy subtypes. Together, these findings provide leads for epilepsy therapies based on underlying pathophysiology.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/854982
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