Redox abnormalities are at the crossroad of cardiovascular diseases, cancer and cardiotoxicity from anticancer treatments. Indeed, disturbances of the redox equilibrium are common drivers of these conditions. Not only is an increase in oxidative stress a fundamental mechanism of action of anthracyclines (which have historically been the most studied anticancer treatments) but also this is at the basis of the toxic cardiovascular effects of antineoplastic targeted drugs and radiotherapy. Here we examine the oxidative mechanisms involved in the different cardiotoxicities induced by the main redox-based antineoplastic treatments, and discuss novel approaches for the treatment of such toxicities.

Oxidative stress in anticancer therapies-related cardiac dysfunction / Attanasio, U.; Pirozzi, F.; Poto, R.; Cuomo, A.; Carannante, A.; Russo, M.; Ghigo, A.; Hirsch, E.; Tocchetti, C. G.; Varricchi, G.; Mercurio, V.. - In: FREE RADICAL BIOLOGY & MEDICINE. - ISSN 0891-5849. - 169:(2021), pp. 410-415. [10.1016/j.freeradbiomed.2021.04.021]

Oxidative stress in anticancer therapies-related cardiac dysfunction

Attanasio U.;Pirozzi F.;Poto R.;Cuomo A.;Carannante A.;Russo M.;Hirsch E.;Tocchetti C. G.
;
Varricchi G.;Mercurio V.
2021

Abstract

Redox abnormalities are at the crossroad of cardiovascular diseases, cancer and cardiotoxicity from anticancer treatments. Indeed, disturbances of the redox equilibrium are common drivers of these conditions. Not only is an increase in oxidative stress a fundamental mechanism of action of anthracyclines (which have historically been the most studied anticancer treatments) but also this is at the basis of the toxic cardiovascular effects of antineoplastic targeted drugs and radiotherapy. Here we examine the oxidative mechanisms involved in the different cardiotoxicities induced by the main redox-based antineoplastic treatments, and discuss novel approaches for the treatment of such toxicities.
2021
Oxidative stress in anticancer therapies-related cardiac dysfunction / Attanasio, U.; Pirozzi, F.; Poto, R.; Cuomo, A.; Carannante, A.; Russo, M.; Ghigo, A.; Hirsch, E.; Tocchetti, C. G.; Varricchi, G.; Mercurio, V.. - In: FREE RADICAL BIOLOGY & MEDICINE. - ISSN 0891-5849. - 169:(2021), pp. 410-415. [10.1016/j.freeradbiomed.2021.04.021]
File in questo prodotto:
File Dimensione Formato  
2021 attanasio pirozzi frbm 1-s2.0-S0891584921002288-main.pdf

solo utenti autorizzati

Licenza: Accesso privato/ristretto
Dimensione 1.58 MB
Formato Adobe PDF
1.58 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/854448
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 5
social impact