Aim: To assess the value of bone scintigraphy and 18F-fluorocholine PET/computed tomography (CT) in predicting outcome in patients with prostate cancer and bone metastases treated with 223radium. Materials & methods: Retrospective analysis of 48 patients that underwent 223radium therapy. End points were pain relief and overall survival. Results: After therapy, pain relief was observed in 27 patients. Patients without pain relief had more bone lesions at PET/CT than at bone scintigraphy (pre-therapy imaging mismatch). In 39 patients who completed treatment protocol, post-therapy alkaline phosphatase and pre-therapy imaging mismatch were independent predictors of poor overall survival. Conclusion: Patients with more lesions at 18F-fluorocholine PET/CT than at bone scintigraphy had a poor prognosis. The combined imaging approach could be useful to predict outcome after 223radium therapy.

Combined bone scintigraphy and fluorocholine PET/computed tomography predicts response to radium-223 therapy in patients with prostate cancer / Klain, Michele; Gaudieri, Valeria; Petretta, Mario; Zampella, Emilia; Storto, Giovanni; Nappi, Carmela; Buonerba, Carlo; Crocetto, Felice; Gallicchio, Rosj; Volpe, Fabio; Pace, Leonardo; Schlumberger, Martin; Cuocolo, Alberto. - In: FUTURE SCIENCE OA. - ISSN 2056-5623. - 7:8(2021), pp. 719-729. [10.2144/fsoa-2021-0053]

Combined bone scintigraphy and fluorocholine PET/computed tomography predicts response to radium-223 therapy in patients with prostate cancer

Klain, Michele;Gaudieri, Valeria;Zampella, Emilia;Nappi, Carmela;Buonerba, Carlo;Crocetto, Felice;Volpe, Fabio;Cuocolo, Alberto
2021

Abstract

Aim: To assess the value of bone scintigraphy and 18F-fluorocholine PET/computed tomography (CT) in predicting outcome in patients with prostate cancer and bone metastases treated with 223radium. Materials & methods: Retrospective analysis of 48 patients that underwent 223radium therapy. End points were pain relief and overall survival. Results: After therapy, pain relief was observed in 27 patients. Patients without pain relief had more bone lesions at PET/CT than at bone scintigraphy (pre-therapy imaging mismatch). In 39 patients who completed treatment protocol, post-therapy alkaline phosphatase and pre-therapy imaging mismatch were independent predictors of poor overall survival. Conclusion: Patients with more lesions at 18F-fluorocholine PET/CT than at bone scintigraphy had a poor prognosis. The combined imaging approach could be useful to predict outcome after 223radium therapy.
2021
Combined bone scintigraphy and fluorocholine PET/computed tomography predicts response to radium-223 therapy in patients with prostate cancer / Klain, Michele; Gaudieri, Valeria; Petretta, Mario; Zampella, Emilia; Storto, Giovanni; Nappi, Carmela; Buonerba, Carlo; Crocetto, Felice; Gallicchio, Rosj; Volpe, Fabio; Pace, Leonardo; Schlumberger, Martin; Cuocolo, Alberto. - In: FUTURE SCIENCE OA. - ISSN 2056-5623. - 7:8(2021), pp. 719-729. [10.2144/fsoa-2021-0053]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/852164
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