Dopamine (DA) is a key neurotransmitter involved in multiple physiological functions including motor control, modulation of affective and emotional states, reward mechanisms, reinforcement of behavior, and selected higher cognitive functions. Dysfunction in dopaminergic transmission is recognized as a core alteration in several devastating neurological and psychiatric disorders, including Parkinson's disease (PD), schizophrenia, bipolar disorder, attention deficit hyperactivity disorder (ADHD) and addiction. Here we will discuss the current insights on the role of DA in motor control and reward learning mechanisms and its involvement in the modulation of synaptic dynamics through different pathways. In particular, we will consider the role of DA as neuromodulator of two forms of synaptic plasticity, known as long-term potentiation (LTP) and long-term depression (LTD) in several cortical and subcortical areas. Finally, we will delineate how the effect of DA on dendritic spines places this molecule at the interface between the motor and the cognitive systems. Specifically, we will be focusing on PD, vascular dementia, and schizophrenia.

Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control / Speranza, L.; di Porzio, U.; Viggiano, D.; de Donato, A.; Volpicelli, F.. - In: CELLS. - ISSN 2073-4409. - 10:4(2021), p. 735. [10.3390/cells10040735]

Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control

Speranza L.
Primo
;
Viggiano D.;Volpicelli F.
Ultimo
2021

Abstract

Dopamine (DA) is a key neurotransmitter involved in multiple physiological functions including motor control, modulation of affective and emotional states, reward mechanisms, reinforcement of behavior, and selected higher cognitive functions. Dysfunction in dopaminergic transmission is recognized as a core alteration in several devastating neurological and psychiatric disorders, including Parkinson's disease (PD), schizophrenia, bipolar disorder, attention deficit hyperactivity disorder (ADHD) and addiction. Here we will discuss the current insights on the role of DA in motor control and reward learning mechanisms and its involvement in the modulation of synaptic dynamics through different pathways. In particular, we will consider the role of DA as neuromodulator of two forms of synaptic plasticity, known as long-term potentiation (LTP) and long-term depression (LTD) in several cortical and subcortical areas. Finally, we will delineate how the effect of DA on dendritic spines places this molecule at the interface between the motor and the cognitive systems. Specifically, we will be focusing on PD, vascular dementia, and schizophrenia.
2021
Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control / Speranza, L.; di Porzio, U.; Viggiano, D.; de Donato, A.; Volpicelli, F.. - In: CELLS. - ISSN 2073-4409. - 10:4(2021), p. 735. [10.3390/cells10040735]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/850907
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