Purpose: Topical cosmetic agents if correctly prescribed and used may improve outcomes in acne therapy. The aim of this study was to assess the efficacy and tolerability of a new daily cosmetic regimen in the treatment of mild facial acne. Patients and methods: A multicenter, prospective, observational, clinical study was conducted on 91 adult patients with mild acne. Subjects were instructed to apply a fluid containing Licochalcone A/Salicylic acid/L-Carnitine in the morning and a cream with Licochalcone A/Hydroxy-Complex 10% at bedtime for 8 weeks. The efficacy was clinically evaluated by Global Acne Grading System (GAGS) score and by comedones/papules lesions count and by instrumental assessment (Sebutape™and Reveal Photo Imager/VISIA-CR™ imaging) at baseline, at 4 and 8 weeks. Results: At 4 weeks a statistically significant reduction from baseline of GAGSwas observed. In addition, the mean total count of comedones and papules was significantly reduced by 41% and 45%, respectively, from baseline along with a significant reduction of mean sebum of 47%. At 8 weeks, a further statistically significant reduction from baseline of GAGS, total count of comedones and papules (64% and 71%, respectively), along with an additional sebum reduction of about 52% was also recorded. Conclusion: Our results suggest that the daily regimen based on Licochalcone A with Salicylic acid/L-Carnitine as fluid or with Hydroxy-Complex 10% as cream represent an interesting cosmetic approach for treating mild acne.

Licochalcone a in combination with salicylic acid as fluid based and hydroxy-complex 10% cream for the treatment of mild acne: A multicenter prospective trial / Dall'Oglio, F.; Fabbrocini, G.; Tedeschi, A.; Donnarumma, M.; Chiodini, P.; Micali, G.. - In: CLINICAL, COSMETIC AND INVESTIGATIONAL DERMATOLOGY. - ISSN 1178-7015. - 12:(2019), pp. 961-967. [10.2147/CCID.S206935]

Licochalcone a in combination with salicylic acid as fluid based and hydroxy-complex 10% cream for the treatment of mild acne: A multicenter prospective trial

Fabbrocini G.;Donnarumma M.;Chiodini P.;
2019

Abstract

Purpose: Topical cosmetic agents if correctly prescribed and used may improve outcomes in acne therapy. The aim of this study was to assess the efficacy and tolerability of a new daily cosmetic regimen in the treatment of mild facial acne. Patients and methods: A multicenter, prospective, observational, clinical study was conducted on 91 adult patients with mild acne. Subjects were instructed to apply a fluid containing Licochalcone A/Salicylic acid/L-Carnitine in the morning and a cream with Licochalcone A/Hydroxy-Complex 10% at bedtime for 8 weeks. The efficacy was clinically evaluated by Global Acne Grading System (GAGS) score and by comedones/papules lesions count and by instrumental assessment (Sebutape™and Reveal Photo Imager/VISIA-CR™ imaging) at baseline, at 4 and 8 weeks. Results: At 4 weeks a statistically significant reduction from baseline of GAGSwas observed. In addition, the mean total count of comedones and papules was significantly reduced by 41% and 45%, respectively, from baseline along with a significant reduction of mean sebum of 47%. At 8 weeks, a further statistically significant reduction from baseline of GAGS, total count of comedones and papules (64% and 71%, respectively), along with an additional sebum reduction of about 52% was also recorded. Conclusion: Our results suggest that the daily regimen based on Licochalcone A with Salicylic acid/L-Carnitine as fluid or with Hydroxy-Complex 10% as cream represent an interesting cosmetic approach for treating mild acne.
2019
Licochalcone a in combination with salicylic acid as fluid based and hydroxy-complex 10% cream for the treatment of mild acne: A multicenter prospective trial / Dall'Oglio, F.; Fabbrocini, G.; Tedeschi, A.; Donnarumma, M.; Chiodini, P.; Micali, G.. - In: CLINICAL, COSMETIC AND INVESTIGATIONAL DERMATOLOGY. - ISSN 1178-7015. - 12:(2019), pp. 961-967. [10.2147/CCID.S206935]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/849784
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