Locally advanced basal cell carcinoma had always represented a form of skin cancer which had been difficult to treat until the hedgehog inhibitor vismodegib was approved. This small molecule acts by inhibiting the hedgehog signaling pathway that plays a critical role in the process of tumorigenesis. Although several trials have demonstrated the high efficacy of this drug, different adverse events have been described. Muscle spasms, dysgeusia, weight loss, and alopecia are the adverse events most frequently reported. The objective of this study was to report the incidence of alopecia arising in patients treated with vismodegib, assessing its characteristics, grade of severity, and time of onset.

Hair Loss in Patients Treated with Vismodegib: A Single-Center Retrospective Study / Villani, A.; Fabbrocini, G.; Costa, C.; Scalvenzi, M.. - In: SKIN APPENDAGE DISORDERS. - ISSN 2296-9195. - 6:5(2020), pp. 280-282. [10.1159/000508825]

Hair Loss in Patients Treated with Vismodegib: A Single-Center Retrospective Study

Villani A.;Fabbrocini G.;Costa C.;Scalvenzi M.
2020

Abstract

Locally advanced basal cell carcinoma had always represented a form of skin cancer which had been difficult to treat until the hedgehog inhibitor vismodegib was approved. This small molecule acts by inhibiting the hedgehog signaling pathway that plays a critical role in the process of tumorigenesis. Although several trials have demonstrated the high efficacy of this drug, different adverse events have been described. Muscle spasms, dysgeusia, weight loss, and alopecia are the adverse events most frequently reported. The objective of this study was to report the incidence of alopecia arising in patients treated with vismodegib, assessing its characteristics, grade of severity, and time of onset.
2020
Hair Loss in Patients Treated with Vismodegib: A Single-Center Retrospective Study / Villani, A.; Fabbrocini, G.; Costa, C.; Scalvenzi, M.. - In: SKIN APPENDAGE DISORDERS. - ISSN 2296-9195. - 6:5(2020), pp. 280-282. [10.1159/000508825]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/849544
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