In-depth characterization of heart-brain communication in critically ill patients with severe acute respiratory failure is attracting significant interest in the COronaVIrus Disease 19 (COVID-19) pandemic era during intensive care unit (ICU) stay and after ICU or hospital discharge. Emerging research has provided new insights into pathogenic role of the deregulation of the heart-brain axis (HBA), a bidirectional flow of information, in leading to severe multiorgan disease syndrome (MODS) in patients with confirmed infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Noteworthy, HBA dysfunction may worsen the outcome of the COVID-19 patients. In this review, we discuss the critical role HBA plays in both promoting and limiting MODS in COVID-19. We also highlight the role of HBA as new target for novel therapeutic strategies in COVID-19 in order to open new translational frontiers of care. This is a translational perspective from the Italian Society of Cardiovascular Researches.
Understanding the Heart-Brain Axis Response in COVID-19 patients: a Suggestive Perspective for Therapeutic Development / Lionetti, Vincenzo; Bollini, Sveva; Coppini, Raffaele; Gerbino, Andrea; Ghigo, Alessandra; Iaccarino, Guido; Madonna, Rosalinda; Mangiacapra, Fabio; Miragoli, Michele; Moccia, Francesco; Munaron, Luca; Pagliaro, Pasquale; Parenti, Astrid; Pasqua, Teresa; Penna, Claudia; Quaini, Federico; Rocca, Carmine; Samaja, Michele; Sartiani, Laura; Soda, Teresa; Tocchetti, Carlo Gabriele; Angelone, Tommaso. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - (2021), p. 105581. [10.1016/j.phrs.2021.105581]
Understanding the Heart-Brain Axis Response in COVID-19 patients: a Suggestive Perspective for Therapeutic Development
Iaccarino, Guido;Tocchetti, Carlo Gabriele;
2021
Abstract
In-depth characterization of heart-brain communication in critically ill patients with severe acute respiratory failure is attracting significant interest in the COronaVIrus Disease 19 (COVID-19) pandemic era during intensive care unit (ICU) stay and after ICU or hospital discharge. Emerging research has provided new insights into pathogenic role of the deregulation of the heart-brain axis (HBA), a bidirectional flow of information, in leading to severe multiorgan disease syndrome (MODS) in patients with confirmed infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Noteworthy, HBA dysfunction may worsen the outcome of the COVID-19 patients. In this review, we discuss the critical role HBA plays in both promoting and limiting MODS in COVID-19. We also highlight the role of HBA as new target for novel therapeutic strategies in COVID-19 in order to open new translational frontiers of care. This is a translational perspective from the Italian Society of Cardiovascular Researches.File | Dimensione | Formato | |
---|---|---|---|
2021 lionetti covid sirc 1-s2.0-S1043661821001651-main.pdf
solo utenti autorizzati
Licenza:
Accesso privato/ristretto
Dimensione
1.86 MB
Formato
Adobe PDF
|
1.86 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.