Along with epidemiologic transitions of the global population, the burden of aortic stenosis (AS) is rapidly increasing and transcatheter aortic valve replacement (TAVR) has quickly spread; indeed, it is nowadays also employed in treating patients with AS at intermediate operative risk. Nonetheless, the less invasive interventional strategy still carries relevant issues concerning post-procedural optimal antithrombotic strategy, given the current indications provided by guidelines are not completely supported by evidence-based data. Geriatric patients suffer from high bleeding and thromboembolic risks, whose balance is particularly subtle due to the presence of concomitant conditions, such as atrial fibrillation and chronic kidney disease, that make the post-TAVR antithrombotic management particularly insidious. This scenario is further complicated by the lack of specific evidence regarding the 'real-life' complex conditions typical of the geriatric syndromes, thus, the management of such a heterogeneous population, ranging from healthy ageing to frailty, is far from being defined. The aim of the present review is to summarize the critical points and the most updated evidence regarding the post-TAVR antithrombotic approach in the geriatric population, with a specific focus on the most frequent clinical settings.
Antithrombotic therapy in patients undergoing transcatheter aortic valve replacement: the complexity of the elderly / Bencivenga, Leonardo; Sepe, Immacolata; Palaia, Maria Emiliana; Komici, Klara; Corbi, Graziamaria; Puzone, Brunella; Arcopinto, Michele; Cittadini, Antonio; Ferrara, Nicola; Femminella, Grazia Daniela; Rengo, Giuseppe. - In: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY. - ISSN 2047-4873. - 28:1(2021), pp. 87-97. [10.1093/eurjpc/zwaa053]
Antithrombotic therapy in patients undergoing transcatheter aortic valve replacement: the complexity of the elderly
Bencivenga, Leonardo;Sepe, Immacolata;Palaia, Maria Emiliana;Corbi, Graziamaria;Puzone, Brunella;Arcopinto, Michele;Cittadini, Antonio;Ferrara, Nicola;Femminella, Grazia Daniela;Rengo, Giuseppe
2021
Abstract
Along with epidemiologic transitions of the global population, the burden of aortic stenosis (AS) is rapidly increasing and transcatheter aortic valve replacement (TAVR) has quickly spread; indeed, it is nowadays also employed in treating patients with AS at intermediate operative risk. Nonetheless, the less invasive interventional strategy still carries relevant issues concerning post-procedural optimal antithrombotic strategy, given the current indications provided by guidelines are not completely supported by evidence-based data. Geriatric patients suffer from high bleeding and thromboembolic risks, whose balance is particularly subtle due to the presence of concomitant conditions, such as atrial fibrillation and chronic kidney disease, that make the post-TAVR antithrombotic management particularly insidious. This scenario is further complicated by the lack of specific evidence regarding the 'real-life' complex conditions typical of the geriatric syndromes, thus, the management of such a heterogeneous population, ranging from healthy ageing to frailty, is far from being defined. The aim of the present review is to summarize the critical points and the most updated evidence regarding the post-TAVR antithrombotic approach in the geriatric population, with a specific focus on the most frequent clinical settings.File | Dimensione | Formato | |
---|---|---|---|
Eur J Prev Cardiol'21 Bencivenga.pdf
accesso aperto
Tipologia:
Documento in Post-print
Licenza:
Copyright dell'editore
Dimensione
396.43 kB
Formato
Adobe PDF
|
396.43 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.