Editorial of Special Issue “Genetics and Molecular Pathogenesis of Non-Ischemic Cardiomyopathies”

This editorial aims to summarize the eight scientific papers published in the Special Issue “Genetics and Molecular Pathogenesis of Non-ischemic Cardiomyopathies”. Cardiomyopathies are primary diseases of the myocardium, and are leading causes of sudden cardiac death (SCD), particularly in athletes and the young. Diagnosis of affected individuals remains challenging, and a resolutive therapy is still lacking, as current treatments can only attenuate the symptoms but not prevent or rescue the phenotype (1). Genetics and genomics along with studies in cellular and animal models are fundamental for delineating the genetic bases of cardiomyopathies and to elucidate the pathogenesis of these diseases. This could greatly improve diagnosis and prognostic evaluation of the affected individuals as well as their family members and lead to the identification of novel targets for more effective treatments. The papers published in this Special Issue discuss several aspects of genetics, genomics and mechanistic studies in the field of primary cardiomyopathies