The gene encoding glucose 6-phosphate dehydrogenase (G6PD), which plays a pivotal role in cell defense against oxidative stress, is ubiquitously expressed at widely different levels in various tissues; moreover, G6PD expression is regulated by a number of stimuli. In this study we have analyzed the molecular anatomy of the G6PD core promoter. Our results indicate that the G6PD promoter is more complex than previously assumed; G6PD expression is under the control of several elements that are all required for correct promoter functioning and, furthermore, a still unidentified mammalian specific factor is needed. Copyright (C) 1998 Federation of European Biochemical Societies.
Molecular anatomy of the human glucose 6-phosphate dehydrogenase core promoter / Franze', Annamaria; Ferrante, M. I.; Fusco, F.; Santoro, A.; Sanzari, E.; Martini, G.; Ursini, M. V.. - In: FEBS LETTERS. - ISSN 0014-5793. - 437:3(1998), pp. 313-318. [10.1016/S0014-5793(98)01259-9]
Molecular anatomy of the human glucose 6-phosphate dehydrogenase core promoter
Annamaria Franzè
Primo
;
1998
Abstract
The gene encoding glucose 6-phosphate dehydrogenase (G6PD), which plays a pivotal role in cell defense against oxidative stress, is ubiquitously expressed at widely different levels in various tissues; moreover, G6PD expression is regulated by a number of stimuli. In this study we have analyzed the molecular anatomy of the G6PD core promoter. Our results indicate that the G6PD promoter is more complex than previously assumed; G6PD expression is under the control of several elements that are all required for correct promoter functioning and, furthermore, a still unidentified mammalian specific factor is needed. Copyright (C) 1998 Federation of European Biochemical Societies.File | Dimensione | Formato | |
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