Many studies investigating the transcriptional control of adipogenesis have been published so far; recently the research is focusing on the role of epigenetic mechanisms in regulating the process of adipocyte development. Histone-modifying enzymes and the histone tails post-transcriptional modifications catalyzed by them, are fundamentally involved in the epigenetic regulation of adipogenesis. In our review, we will discuss recent advances in epigenomic regulation of adipogenesis with a focus on histone-modifying enzymes implicated in the various phases of adipocytes differentiation process from mesenchymal stem cells to mature adipocytes. Understanding adipogenesis, may provide new ways to treat obesity and related metabolic diseases.

Epigenetic regulation of adipogenesis by histone-modifying enzymes / Macchia, Paolo Emidio; Nettore, Immacolata Cristina; Franchini, Fabiana; Santana-Viera, Laura; Ungaro, Paola. - In: EPIGENOMICS. - ISSN 1750-1911. - 13:3(2021), pp. 235-251. [10.2217/epi-2020-0304]

Epigenetic regulation of adipogenesis by histone-modifying enzymes

Macchia, Paolo Emidio;Nettore, Immacolata Cristina;Franchini, Fabiana;Ungaro, Paola
2021

Abstract

Many studies investigating the transcriptional control of adipogenesis have been published so far; recently the research is focusing on the role of epigenetic mechanisms in regulating the process of adipocyte development. Histone-modifying enzymes and the histone tails post-transcriptional modifications catalyzed by them, are fundamentally involved in the epigenetic regulation of adipogenesis. In our review, we will discuss recent advances in epigenomic regulation of adipogenesis with a focus on histone-modifying enzymes implicated in the various phases of adipocytes differentiation process from mesenchymal stem cells to mature adipocytes. Understanding adipogenesis, may provide new ways to treat obesity and related metabolic diseases.
2021
Epigenetic regulation of adipogenesis by histone-modifying enzymes / Macchia, Paolo Emidio; Nettore, Immacolata Cristina; Franchini, Fabiana; Santana-Viera, Laura; Ungaro, Paola. - In: EPIGENOMICS. - ISSN 1750-1911. - 13:3(2021), pp. 235-251. [10.2217/epi-2020-0304]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/834235
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